PMID: 9182859Jan 1, 1997Paper

The hydrocortisone-induced transcriptional down-regulation of beta-galactoside alpha2,6-sialyltransferase in the small intestine of suckling rats is suppressed by mifepristone (RU-38.486)

The Journal of Steroid Biochemistry and Molecular Biology
A HamrJ Kolínská

Abstract

The progressive loss of sialic acids of the brush-border membrane glycoproteins is one of the major biochemical changes which occur in the rat small intestine during the transition from suckling to weaning, and this process is speeded up by an injection of glucocorticoids to the suckling animals. We used the rat liver beta-galactoside alpha2,6-sialyltransferase (ST6(N), EC 2.4.99.1) cDNA as a probe to examine the mRNA level of this enzyme in the small intestine of both suckling (13-day-old) and weaned (25-day-old) rats. In the ileum of suckling rats, the ST6(N) mRNA level was about four times higher than in the jejunum, whereas the membrane-bound enzyme activity was less than two times higher. In comparison with the controls, hydrocortisone treatment significantly decreased the level of this transcript and of the corresponding enzyme activity in both segments of the small intestine of suckling rats. Additionally, the antiglucocorticoid mifepristone (RU-38.486) suppressed the effect of hydrocortisone. The expression of ST6(N) mRNA in the small intestine of weaned (25-day-old) rats was several times lower than that in suckling (13-day-old) rats, and was unresponsive to hydrocortisone as well as to mifepristone. These results indi...Continue Reading

References

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Citations

Sep 28, 2000·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·V VallejoE Zenteno
May 7, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Marie-Claire Biol-N'garagbaPierre Louisot
Sep 28, 2001·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·C SierraL Vázquez
Apr 5, 2000·Journal of Pediatric Gastroenterology and Nutrition·D DaiW A Walker
Feb 23, 2000·Molecular Cell Biology Research Communications : MCBRC·J P PeyratP Delannoy
Feb 14, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Dingwei DaiW Allan Walker
Nov 24, 1999·The American Journal of Physiology·Y S GunerF K Ghishan

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