The hydrophilic translocator for Vibrio parahaemolyticus, T3SS2, is also translocated.

Infection and Immunity
Xiaohui ZhouToshio Kodama

Abstract

The pathogenesis of the diarrheal disease caused by Vibrio parahaemolyticus, a leading cause of seafood-associated enteritis worldwide, is dependent upon a type III secretion system, T3SS2. This apparatus enables the pathogen to inject bacterial proteins (effectors) into the cytosol of host cells and thereby modulate host processes. T3SS effector proteins transit into the host cell via a membrane pore (translocon) typically formed by 3 bacterial proteins. We have identified the third translocon protein for T3SS2: VopW, which was previously classified as an effector protein for a homologous T3SS in V. cholerae. VopW is a hydrophilic translocon protein; like other such proteins, it is not inserted into the host cell membrane but is required for insertion of the two hydrophobic translocators, VopB2 and VopD2, that constitute the membrane channel. VopW is not required for secretion of T3SS2 effectors into the bacterial culture medium; however, it is essential for transfer of these proteins into the host cell cytoplasm. Consequently, deletion of vopW abrogates the virulence of V. parahaemolyticus in several animal models of diarrheal disease. Unlike previously described hydrophilic translocators, VopW is itself translocated into the...Continue Reading

References

Sep 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·K SekiyaA Abe
Mar 5, 2003·Current Opinion in Microbiology·Claude ParsotAnne-Laure Page
Mar 28, 2003·The Journal of Infectious Diseases·Firdausi QadriG Balakrish Nair
Oct 2, 2004·The Journal of Biological Chemistry·Jennifer E TroskyKim Orth
Oct 27, 2004·Infection and Immunity·Kwon-Sam ParkTakeshi Honda
Feb 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Michelle DziejmanJohn J Mekalanos
Nov 22, 2005·Nature Methods·Jost EnningaGuy Tran Van Nhieu
Jul 25, 2006·Infection and Immunity·Marianela EspinaWendy L Picking
Apr 10, 2007·Food Microbiology·Yi-Cheng Su, Chengchu Liu
Oct 16, 2007·Clinical Microbiology Reviews·Bryan CoburnB Brett Finlay
Oct 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Amy D B LivermanKim Orth
Apr 24, 2008·Molecular Microbiology·C A MuellerG R Cornelis
Dec 25, 2010·The FEBS Journal·Pierre-Jean MatteïAndréa Dessen
Feb 2, 2011·Infection and Immunity·Ashfaqul AlamMichelle Dziejman

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Citations

Nov 6, 2012·The Journal of Microbiology·Hyeilin Ham, Kim Orth
May 21, 2013·International Journal of Food Microbiology·Shing-en TsaiHin-chung Wong
Dec 19, 2019·Microbiology and Immunology·Shigeaki MatsudaToshio Kodama
Nov 27, 2019·Pathogens·Julia A Hotinger, Aaron E May
May 18, 2016·Proceedings of the National Academy of Sciences of the United States of America·Troy P HubbardMatthew K Waldor

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