The hygiene hypothesis at a glance: Early exposures, immune mechanism and novel therapies

Acta Tropica
Gabriel M Alexandre-SilvaManuela B Pucca

Abstract

The hygiene hypothesis was proposed almost three decades ago. Nevertheless, its mechanism still remains with relevant controversies. Some studies defend that early exposures during childhood to microbes and parasites are key determinants to prevent allergies and autoimmune diseases; however, other studies demonstrated that these early exposures can even potentiate the clinical scenario of the diseases. Based on several studies covering the influences of microbiome, parasites, related theories and others, this review focuses on recent advances in the hygiene hypothesis field. In addition, the main immunological mechanisms underlying the hygiene hypothesis are also discussed. We also strongly encourage that researchers do not consider the hygiene hypothesis as a theory based strictly on hygiene habits, but a theory combining diverse influences, as illustrated in this review as the hygiene hypothesis net.

Citations

Jan 29, 2020·The American Journal of Tropical Medicine and Hygiene·Chiara Della BellaAlessandro Bartoloni
Jan 10, 2020·The International Journal of Neuroscience·T Mendes-LimaM M Bernardi
Apr 25, 2019·European Journal of Immunology·Shauna M QuinnKingston H G Mills
Jul 21, 2020·World Journal of Gastroenterology : WJG·Elodie SarronPauline M Anton
Aug 23, 2020·Hormones : International Journal of Endocrinology and Metabolism·Anastasios P MakrisStavroula A Paschou
Aug 25, 2020·Journal of Pediatric Gastroenterology and Nutrition·Mark NomdenJan B F Hulscher
Nov 26, 2020·Evolution, Medicine, and Public Health·Tara J Cepon-Robins, Theresa E Gildner
Dec 3, 2020·Frontiers in Immunology·Marina Andrade BatistaAna Maria Caetano Faria
Dec 18, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Sonia ButaliaDoreen M Rabi
Sep 18, 2020·Journal of Translational Autoimmunity·Belinda M Jackson-ThompsonEdward Mitre
Apr 21, 2021·Scientific Reports·I-Lun ChenChih-Hsing Hung
Apr 28, 2021·Experimental Gerontology·Myriam P Merz, Jonathan D Turner
Apr 20, 2021·Frontiers in Cellular and Infection Microbiology·Dror Avni, Orly Avni
Jul 19, 2021·Autoimmunity Reviews·Amirhossein Azari JafariReza Jafari
Jul 17, 2021·Journal of Pediatric Gastroenterology and Nutrition·Daan van WesselJan Hulscher
Dec 18, 2021·Expert Review of Gastroenterology & Hepatology·Mohammad Amin ShahrbafMassoud Vosough
Dec 8, 2021·Journal of Internal Medicine·Sandra G TednerCaroline Nilsson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Seminars in Fetal & Neonatal Medicine
Steven M Donn, Sunil K Sinha
Blood Cells, Molecules & Diseases
Jeffrey S ChangPatricia A Buffler
Clinical Reviews in Allergy & Immunology
Maria Yazdanbakhsh, Paolo M Matricardi
Deutsche medizinische Wochenschrift
D Voehringer
© 2022 Meta ULC. All rights reserved