PMID: 2498924Jan 1, 1989Paper

The hyperalgesic effect of naloxone is attenuated in streptozotocin-diabetic mice

Psychopharmacology
K RamabadranM M Puig

Abstract

In mice with streptozotocin-induced hyperglycemia, nociception was tested after naloxone administration in hot plate and tail immersion tests. The choice of these two tests was to include a supra-spinal nociceptive reflex indicative of higher cognitive process (hot-plate test) as well as a reflex which predominantly represents lower spinal motor mechanisms (tail immersion test). Naloxone-induced hyperalgesia was attenuated in both tests in mice with streptozotocin-induced diabetes. In mice with hyperglycemia induced by intraperitoneal dextrose administration, naloxone hyperalgesia was significantly enhanced in the hot plate test. The basal nociceptive threshold in streptozotocin-treated animals was decreased in the immersion but not in the hot plate test. These results indicate that hyperglycemia per se does not adequately explain the changes in naloxone hyperalgesia in experimental models of diabetes. They also suggest that acute hyperglycemia may modify the interaction of endogenous opioid peptides with their receptors only at supra-spinal sites. However, chronic hyperglycemia appears to affect endogenous opioid peptides both at spinal and supra-spinal levels and their interaction with the opiate receptors.

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Citations

Nov 11, 2008·Pharmaceutical Research·C S YoonJ H Park
Jun 1, 1989·Pharmacology, Biochemistry, and Behavior·M BansinathM M Puig
Jul 1, 1991·Brain Research Bulletin·M BansinathV K Shukla
Sep 23, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Muragundla Anjaneyulu, Kanwaljit Chopra
Feb 24, 2004·Journal of Medicinal Food·Muragundla AnjaneyuluIndupal Kaur
Sep 24, 2005·Journal of Medicinal Food·Anjali SingalKanwaljit Chopra
Apr 25, 2012·Indian Journal of Pharmacology·Ercan OzdemirAhmet Altun
Feb 18, 2011·Canadian Journal of Physiology and Pharmacology·Ercan OzdemirSinan Gursoy
Jan 1, 1996·Neurochemical Research·T A AmadorD O Souza
Dec 7, 2007·European Journal of Pain : EJP·Anurag KuhadKanwaljit Chopra
Jan 18, 2007·Fundamental & Clinical Pharmacology·Sameer SharmaKanwaljit Chopra
Feb 1, 1996·Metabolism: Clinical and Experimental·T WankeK Irsigler
Sep 1, 2004·European Journal of Pharmacology·Muragundla Anjaneyulu, Kanwaljit Chopra
Jul 28, 2015·Pain Practice : the Official Journal of World Institute of Pain·Rafael Taeho HanHeung Sik Na
Apr 6, 2006·European Journal of Pharmacology·Sameer SharmaKanwaljit Chopra
Apr 22, 2015·The Journal of Physiological Sciences : JPS·Ahmet AltunNedim Durmus
May 28, 2011·Acta Physiologica Hungarica·Ercan OzdemirN Durmus
Apr 9, 2017·Biological Trace Element Research·Taíse F PedrosoMaria Ester Pereira
Nov 15, 2013·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Mumin UnalCaner Mimaroglu
Jun 1, 1990·Natural Product Reports·K W Bentley
Sep 8, 2020·Canadian Journal of Physiology and Pharmacology·Tayfun BaserSinan Gursoy
Apr 27, 2010·The Journal of Pain : Official Journal of the American Pain Society·Kanwaljit ChopraAnurag Kuhad

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