The hyperbolic equilibrium between insulin sensitivity and secretion

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
Giovanni Pacini

Abstract

The interrelationship between insulin resistance and beta cell secretion has been qualitatively described by a hyperbolic function and quantitatively by the disposition index. The concepts behind these assumptions are however still controversial and this review aims to briefly recall the main aspects of the hyperbolic paradigm in terms of mathematical representation and derived indices, together with the main criticisms of the various features. The relationship is analyzed in terms of a qualitative curve with respect to a possible physiological mechanism underlying that particular shape. Quantitatively, the disposition index, which derives from the non-linear hyperbola-like curve, provides an integrated figure of glucose tolerance including both insulin sensitivity and secretion. Different types of metabolic tests and different categories of subjects may yield different mathematical relationships between the two processes. However, various formulas for the disposition index can be wrong and the reasons for this are highlighted. Insulin secretion and insulin sensitivity are related with an inverse, non-linear function that shows the critical importance of the beta cell dysfunction for the development of type 2 diabetes. The disp...Continue Reading

References

Jul 19, 2003·Metabolism: Clinical and Experimental·Bernhard LudvikGiovanni Pacini
Sep 10, 2003·Best Practice & Research. Clinical Endocrinology & Metabolism·Giovanni Pacini, Andrea Mari
Jan 12, 2005·Diabetes, Obesity & Metabolism·B Ahrén, G Pacini

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Citations

Feb 11, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hui Min ChanDavid Z D'Argenio
Nov 18, 2008·American Journal of Respiratory and Critical Care Medicine·Naresh M Punjabi, Brock A Beamer
Feb 22, 2012·Pediatrics·Andrew A BremerRobert H Lustig
Dec 8, 2015·Expert Review of Gastroenterology & Hepatology·Paola DongiovanniLuca Valenti
Dec 22, 2007·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Enzo Bonora
May 9, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A E Rodriguez-RodriguezA Torres
Dec 18, 2012·European Journal of Clinical Investigation·Yvonne WinhoferAlexandra Kautzky-Willer
Apr 16, 2015·International Journal of Endocrinology·Yvonne WinhoferAlexandra Kautzky-Willer
Dec 17, 2015·Diabetic Medicine : a Journal of the British Diabetic Association·S H KimG M Reaven
Jan 19, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Manfred HeckingUNKNOWN European-New-Onset Diabetes After Transplantation Working Group
Jan 30, 2018·Transplant International : Official Journal of the European Society for Organ Transplantation·Leon BergfeldManfred Hecking
Feb 6, 2010·Drugs·Naresh M Punjabi, UNKNOWN Workshop Participants
Oct 3, 2018·The Journal of Rheumatology·Beatriz Tejera-SeguraIván Ferraz-Amaro
May 10, 2016·Endocrine Reviews·Alexandra Kautzky-WillerGiovanni Pacini
May 23, 2009·Transplantation·Adnan Sharif
Jul 11, 2020·Scandinavian Journal of Rheumatology·F GenreI Ferraz-Amaro
Nov 9, 2012·Current Diabetes Reports·Melanie Cree-GreenKristen J Nadeau
May 1, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christian S GöblAlexandra Kautzky-Willer

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