PMID: 19939230Nov 27, 2009Paper

The hyperforin derivative IDN5706 occludes spatial memory impairments and neuropathological changes in a double transgenic Alzheimer's mouse model

Current Alzheimer Research
Waldo F CerpaNibaldo C Inestrosa

Abstract

The use of natural compounds is an interesting stratagem in the search of drugs with therapeutic potential for the treatment of Alzheimer's disease (AD). We report here the effect of the hyperforin derivative (IDN5706, tetrahydrohyperforin), a semi-synthetic derivative of the St. John's Wort, on the brain neuropathology, learning and memory in a double transgenic (APPswe, PS-1dE9) mouse model of AD. Results indicate that, IDN5706 alleviates memory decline induced by amyloid-beta (Abeta) deposits as indicated by the Morris water maze paradigm. Moreover, the analysis of Abeta deposits by immunodetection and thioflavin-S staining of brain sections, only reveals a decrease in the frequency of the larger-size Abeta deposits, suggesting that IDN5706 affected the turnover of amyloid plaques. Immunohistochemical analysis, using GFAP and n-Tyrosine indicated that the hyperforin derivative prevents the inflammatory astrocytic reaction and the oxidative damage triggered by high Abeta deposit levels. We conclude that the hyperforin derivative, IDN5706, has therapeutic potential for prevention and treatment of AD.

Citations

Apr 1, 2014·Cell Communication and Signaling : CCS·Juan A GodoyNibaldo C Inestrosa
Jul 15, 2015·Neural Regeneration Research·Carla Montecinos-OlivaNibaldo C Inestrosa
Aug 20, 2015·Journal of Natural Products·Claudia FracassoMarco Gobbi
Apr 16, 2015·Organic & Biomolecular Chemistry·Jaideep B BharateSandip B Bharate
Feb 4, 2010·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·P A OmololuI J Kade
Sep 20, 2016·Biochemical and Biophysical Research Communications·Elena PopugaevaIlya Bezprozvanny
Jul 14, 2009·The Journal of Surgical Research·Asli Korkmaz, Dürdane Kolankaya
Jun 13, 2018·Antioxidants & Redox Signaling·Elena PopugaevaIlya Bezprozvanny
Jan 31, 2019·Molecular Pharmacology·Elena PopugaevaIlya Bezprozvanny
May 30, 2020·Current Alzheimer Research·Elena PopugaevaIlya Bezprozvanny
Feb 15, 2018·Frontiers in Aging Neuroscience·Md Sahab UddinAdrian M Stankiewicz
Apr 11, 2018·Antioxidants & Redox Signaling·Sarah Mustaly-KalimiGrace E Stutzmann
Feb 21, 2018·Chemical Reviews·Xing-Wei YangGang Xu

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