The hypersensitive induced reaction and leucine-rich repeat proteins regulate plant cell death associated with disease and plant immunity

Molecular Plant-microbe Interactions : MPMI
Hyong Woo ChoiByung Kook Hwang

Abstract

Pathogen-induced programmed cell death (PCD) is intimately linked with disease resistance and susceptibility. However, the molecular components regulating PCD, including hypersensitive and susceptible cell death, are largely unknown in plants. In this study, we show that pathogen-induced Capsicum annuum hypersensitive induced reaction 1 (CaHIR1) and leucine-rich repeat 1 (CaLRR1) function as distinct plant PCD regulators in pepper plants during Xanthomonas campestris pv. vesicatoria infection. Confocal microscopy and protein gel blot analyses revealed that CaLRR1 and CaHIR1 localize to the extracellular matrix and plasma membrane (PM), respectively. Bimolecular fluorescent complementation and coimmunoprecipitation assays showed that the extracellular CaLRR1 specifically binds to the PM-located CaHIR1 in pepper leaves. Overexpression of CaHIR1 triggered pathogen-independent cell death in pepper and Nicotiana benthamiana plants but not in yeast cells. Virus-induced gene silencing (VIGS) of CaLRR1 and CaHIR1 distinctly strengthened and compromised hypersensitive and susceptible cell death in pepper plants, respectively. Endogenous salicylic acid levels and pathogenesis-related gene transcripts were elevated in CaHIR1-silenced plan...Continue Reading

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Citations

Jul 16, 2011·The Journal of Biological Chemistry·Yiping QiFumiaki Katagiri
May 30, 2012·The Plant Journal : for Cell and Molecular Biology·Dong Hyuk LeeByung Kook Hwang
Apr 14, 2012·Plant Signaling & Behavior·Yiping Qi, Fumiaki Katagiri
Sep 26, 2014·Planta·Hyong Woo Choi, Byung Kook Hwang
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Feb 29, 2020·International Journal of Molecular Sciences·Yangyang CaoRuili Li
Jul 28, 2018·Frontiers in Plant Science·Petra JunkováOlga Valentová
Jan 12, 2021·Computational and Structural Biotechnology Journal·Cristina E Alvarez-MartinezChuck S Farah
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Aug 25, 2015·Plant Physiology·Toshiki IshikawaMaki Kawai-Yamada
May 24, 2021·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Na LiZhengqiang Ma

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