The hypolipidemic and pleiotropic effects of rosuvastatin are not enhanced by its association with zinc and selenium supplementation in coronary artery disease patients: a double blind randomized controlled study

PloS One
Karine Cavalcanti Maurício Sena-EvangelistaDulcinéia Saes Parra Abdalla

Abstract

Statins treatment may modify the levels of zinc and selenium, minerals that can improve vascular function and reduce oxidative damage and inflammation in atherosclerotic patients. This study aimed to evaluate the effects of rosuvastatin, alone or associated with zinc and selenium supplementation, on lipid profile, antioxidant enzymes and mineral status in coronary artery disease patients. A double-blind randomized clinical trial was performed in which patients (n = 76) were treated with 10 mg rosuvastatin over 4 months associated or not with zinc (30 mg/d) and selenium (150 μg/d) supplementation. The following parameters were analyzed before and after the intervention: anthropometric measurements, lipid profile, high sensitivity C-reactive protein (hs-CRP), electronegative low density lipoprotein (LDL(-)) concentrations, activities of glutathione peroxidase (GPx), superoxide dismutase (SOD), zinc and selenium concentrations in blood plasma and erythocytes. Significance was determined using an α of 5% (two-tailed). We found that rosuvastatin therapy was efficient in reducing total cholesterol, LDL-cholesterol, non-HDL cholesterol, triglycerides, and hs-CRP independently of mineral supplementation. Neither treatment was associate...Continue Reading

Associated Clinical Trials

Mar 7, 2012·Karine C M Sena-Evangelista

References

Oct 1, 1991·European Journal of Drug Metabolism and Pharmacokinetics·J NèveJ Fontaine
Jan 1, 1997·European Journal of Clinical Pharmacology·W LeonhardtM Hanefeld
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Aug 5, 2003·Journal of the American College of Nutrition·Anne-Marie RousselRichard A Anderson
Feb 6, 2004·The British Journal of Nutrition·John H Beattie, In-Sook Kwun
Apr 10, 2004·Biological Trace Element Research·M Ilker YilmazI Hakki Kocar
Sep 29, 2004·Free Radical Biology & Medicine·Ananda S PrasadFazlul H Sarkar
Sep 30, 2004·Free Radical Biology & Medicine·Edimar C PereiraDulcineia S P Abdalla
Nov 16, 2004·Trends in Cardiovascular Medicine·Bernd Moosmann, Christian Behl
Jul 22, 2005·Biological Trace Element Research·Karine Cavalcanti Mauricio de SenaLucia de Fãtima Campos Pedrosa
Aug 16, 2005·Molecular Aspects of Medicine·Felicity Johnson, Cecilia Giulivi
Oct 26, 2005·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Majid Ghayour-MobarhanGordon A A Ferns
Nov 30, 2005·Atherosclerosis·A C KalioraH Schmidt
Dec 20, 2005·The American Journal of Cardiology·Protásio L da LuzEliana S Cerqueira
Apr 15, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Raymond F BurkDaniel W Byrne
Jun 20, 2006·Clinical Biochemistry·Jair A OliveiraDulcineia S P Abdalla
Sep 21, 2006·European Heart Journal·Da-Yi HuUNKNOWN China Heart Survey Group
May 25, 2007·The British Journal of Nutrition·D LópezM T Mitjavila
Aug 19, 2007·Toxicology and Applied Pharmacology·Maria Skaalum PetersenKim Brøsen
Dec 7, 2007·Experimental Gerontology·Ananda S Prasad
Apr 17, 2008·The Proceedings of the Nutrition Society·K Richard Bruckdorfer
Nov 11, 2008·Current Pharmaceutical Design·E MocchegianiF Lattanzio
Dec 6, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Tanize do Espírito Santo FaulinDulcineia Saes Parra Abdalla
Feb 11, 2009·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Josiane ArnaudAnne-Marie Roussel
May 8, 2009·The American Journal of Clinical Nutrition·Kate AshtonSusan J Fairweather-Tait
May 14, 2009·Vascular Health and Risk Management·Paolo RubbaMarco Gentile
Mar 1, 2008·Environmental Health and Preventive Medicine·Ujang Tinggi
Nov 13, 2009·Antioxidants & Redox Signaling·Laura V PappKum Kum Khanna
Mar 5, 2010·The American Journal of Clinical Nutrition·Susan J Fairweather-TaitRachel Hurst
Oct 19, 2010·Nutrition·Peter J LittleIrina L Korichneva
Jul 5, 2012·Molecular Nutrition & Food Research·Stéphane TanguyFrançois Boucher
May 17, 2013·Chonnam Medical Journal·Sang Yup Lim
Nov 14, 2013·Journal of the American College of Nutrition·Dominik D AlexanderLaura Elkayam
Feb 4, 2014·Oxidative Medicine and Cellular Longevity·Matilde Otero-LosadaJosé Milei

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Citations

Mar 23, 2021·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Merve Nur CeylanNuray Yazihan

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Methods Mentioned

BETA
percutaneous coronary angioplasty
immunosorbent assay

Clinical Trials Mentioned

NCT01547377

Software Mentioned

Stata

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