PMID: 3753079Sep 1, 1986Paper

The hypoplastic left heart syndrome: evidence of preoperative myocardial and hepatic infarction in spite of prostaglandin therapy

The Annals of Thoracic Surgery
D S MoodieN B Ratliff

Abstract

From February, 1983, to November, 1984, 11 infants with hypoplastic left heart syndrome were managed medically prior to operative intervention. Only 2 of the 11 infants appeared to be in mild distress at birth. Despite relatively normal Apgar scores, 9 of the infants were seen in shock. All patients were managed medically with fluid restriction, diuretics, and the institution of prostaglandin E1. There was a marked improvement in arterial pH from a mean value of 7.13 prior to prostaglandin to 7.42 following prostaglandin infusion. There was also a dramatic decrease in the serum creatinine level from a mean pretreatment level of 1.5 mg/dl to 0.7 mg/dl following infusion. Ten of the 11 infants were operated on at a mean age of 4 days with a Norwood or conduit procedure. Three infants who died at 3, 13, and 24 days of age had sustained myocardial infarctions prior to operation. Three patients also had multiple infarcts of the liver. Three patients are alive 23, 22, and 6 months after operation, and are growing and developing normally. The ability to maintain the infant with hypoplastic left heart syndrome in a stable hemodynamic condition has made surgical palliation a realistic option for this otherwise fatal anomaly. Nevertheles...Continue Reading

References

Jul 1, 1976·Acta paediatrica Scandinavica·P JunkerJ Kamper
Apr 2, 1970·The New England Journal of Medicine·G G CaylerG E Miller
Jan 1, 1970·The Journal of Pediatrics·H J WiggerW A Blanc
Feb 1, 1972·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·R C Ablow, E L Effman
Jan 1, 1980·The American Journal of Cardiology·W I NorwoodS P Sanders
Jan 1, 1983·Cleveland Clinic Quarterly·C C GillR Sterba
Sep 1, 1981·The Annals of Thoracic Surgery·D M Behrendt, A Rocchini
Dec 1, 1981·Journal of Pediatric Surgery·J A O'NeillM L Born

❮ Previous
Next ❯

Citations

Mar 23, 2013·Pediatric Cardiology·Jeffrey H Shuhaiber, Frank A Pigula
Jul 1, 1989·The Annals of Thoracic Surgery·R A GustafsonG E Rozar
Nov 1, 1994·Journal of Clinical Anesthesia·L TestaA Kavanaugh-McHugh
Apr 1, 1993·Journal of Pediatric Surgery·A HebraA J Ross
Aug 4, 2001·Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual·Ralph S. Mosca, Edward L. Bove
Jul 4, 2001·The Journal of Thoracic and Cardiovascular Surgery·Y SaikiI M Rebeyka
Jan 1, 1990·Pediatric Pathology·V D AielloG Thiene
May 9, 2006·The Journal of Thoracic and Cardiovascular Surgery·Jürgen StiehHans Heiner Kramer
Apr 2, 2008·Congenital Heart Disease·John T BenjaminRobert L Schelonka

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.