The Hypothalamic Arcuate Nucleus-Median Eminence Is a Target for Sustained Diabetes Remission Induced by Fibroblast Growth Factor 1

Diabetes
Jenny M BrownMichael W Schwartz

Abstract

In rodent models of type 2 diabetes (T2D), sustained remission of diabetic hyperglycemia can be induced by a single intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1). To identify the brain areas responsible for this effect, we first used immunohistochemistry to map the hypothalamic distribution of phosphorylated extracellular signal-related kinase 1/2 (pERK1/2), a marker of mitogen-activated protein kinase-ERK signal transduction downstream of FGF receptor activation. Twenty minutes after icv FGF1 injection in adult male Wistar rats, pERK1/2 staining was detected primarily in two hypothalamic areas: the arcuate nucleus-median eminence (ARC-ME) and the paraventricular nucleus (PVN). To determine whether an action of FGF1 localized to either the ARC-ME or the PVN is capable of mimicking the sustained antidiabetic effect elicited by icv FGF1, we microinjected either saline vehicle or a low dose of FGF1 (0.3 µg/side) bilaterally into either the ARC-ME area or PVN of Zucker Diabetic Fatty rats, a model of T2D, and monitored daily food intake, body weight, and blood glucose levels over a 3-week period. Whereas bilateral intra-arcuate microinjection of saline vehicle was without effect, remission of hypergly...Continue Reading

References

Jun 1, 2000·Metabolism: Clinical and Experimental·G J Etgen, B A Oldham
Dec 17, 2011·Science Translational Medicine·Ai-Luen WuJunichiro Sonoda
Dec 29, 2011·The Journal of Clinical Investigation·Joshua P ThalerMichael W Schwartz
Feb 14, 2013·Science Signaling·Malgorzata ZakrzewskaAntoni Wiedlocha
Oct 3, 2013·The Journal of Clinical Investigation·Gregory J MortonMichael W Schwartz
Jun 18, 2015·Journal of Cellular and Molecular Medicine·Roberto Elizondo-VegaMaria A García-Robles
Mar 12, 2016·Experimental & Molecular Medicine·Eun RohMin-Seon Kim
Mar 24, 2016·Proceedings of the National Academy of Sciences of the United States of America·Thomas H MeekGregory J Morton
Jun 13, 2017·Diabetes·Jennifer D DeemMichael W Schwartz
Mar 29, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Richard C RogersGerlinda E Hermann
Dec 14, 2018·Diabetes·Jarrad M ScarlettMichael W Schwartz
Dec 12, 2018·Cell Metabolism·Marie Aare BentsenMichael W Schwartz

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Citations

Sep 8, 2020·Diabetologia·Chelsea L FaberGregory J Morton
Jul 23, 2019·The Journal of Clinical Investigation·Jenny M BrownMichael W Schwartz
Aug 6, 2019·The Journal of Clinical Investigation·Kerstin StemmerMatthias H Tschöp
Oct 13, 2020·Diabetologia·Kimberly M AlongeMichael W Schwartz
Apr 8, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Matei Bolborea, Fanny Langlet
Nov 5, 2020·Cell Metabolism·Giuseppe Gangarossa, Serge Luquet
Jun 22, 2021·Metabolism: Clinical and Experimental·Taylor LandryHu Huang
Jun 24, 2021·Nature Metabolism·Martin G MyersMichael W Schwartz
Jan 7, 2022·Annual Review of Pharmacology and Toxicology·Zaman MirzadehMichael W Schwartz

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