The Hypothalamic Inflammatory/Gliosis Response to Neonatal Overnutrition Is Sex and Age Dependent

Endocrinology
Pilar Argente-ArizónJulie A Chowen

Abstract

Astrocytes participate in both physiological and pathophysiological responses to metabolic and nutrient signals. Although most studies have focused on the astrocytic response to weight gain due to high-fat/high-carbohydrate intake, surplus intake of a balanced diet also induces excess weight gain. We have accessed the effects of neonatal overnutrition, which has both age- and sex-dependent effects on weight gain, on hypothalamic inflammation/gliosis. Although both male and female Wistar rats accumulate excessive fat mass as early as postnatal day (PND) 10 with neonatal overnutrition, no increase in hypothalamic cytokine levels, markers of astrocytes or microglia, or inflammatory signaling pathways were observed. At PND 50, no effect of neonatal overnutriton was found in either sex, whereas at PND 150, males again weighed significantly more than their controls, and this was coincident with an increase in markers of inflammation and astrogliosis in the hypothalamus. Circulating triglycerides and free fatty acids were also elevated in these males, but not in females or in either sex at PND 10. Thus, the effects of fatty acids and estrogens on astrocytes in vitro were analyzed. Our results indicate that changes in circulating fatty...Continue Reading

References

Mar 1, 1991·The American Journal of Clinical Nutrition·S M LopesG L Blackburn
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Mar 1, 1995·Trends in Neurosciences·N J Rothwell, S J Hopkins
Aug 12, 1998·The Journal of Steroid Biochemistry and Molecular Biology·I Jung-Testas, E E Baulieu
Aug 26, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S KokaR A Reinhardt
Jul 21, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·F C GomesV Moura Neto
Apr 15, 2000·Nature·J M Friedman
Oct 3, 2000·Endocrinology·A J Bruce-KellerM P Mattson
Feb 17, 2001·Nitric Oxide : Biology and Chemistry·K M MirandaD A Wink
Sep 8, 2001·Progress in Brain Research·R C MelcangiL Martini
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Oct 16, 2002·Glia·Uwe-Karsten Hanisch
Nov 26, 2002·Nature·Jiro HirosumiGökhan S Hotamisligil
Mar 11, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rebecca StarkieBente Klarlund Pedersen
Jan 15, 1953·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·G C KENNEDY
Mar 23, 2006·Nature Reviews. Neuroscience·Mark P Mattson, Tim Magnus
May 5, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Saurav BrahmachariKalipada Pahan
Jul 11, 2006·The Journal of Clinical Investigation·Steven E ShoelsonAllison B Goldfine
Feb 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sergei MusatovSonoko Ogawa
Jul 11, 2007·Journal of Neuroendocrinology·S G Bouret, R B Simerly
Aug 8, 2007·Cell Metabolism·Liora CaspiTony K T Lam
Jan 4, 2008·Acta Physiologica·S Glund, A Krook
Sep 11, 2008·Neuroimmunomodulation·Lício A VellosoCláudio T de Souza
Jan 1, 2009·American Journal of Physiology. Endocrinology and Metabolism·Kelly A PoseyKevin D Niswender
Jan 16, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marciane MilanskiLício A Velloso

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Citations

Apr 13, 2018·Journal of Neuroendocrinology·Y ÁvalosM Dorfman
Dec 19, 2018·Journal of Neuroendocrinology·Julie A ChowenMaría Soledad Fernández-Alfonso
Jan 20, 2018·Endocrine Reviews·Vincent PrevotJerome Clasadonte
Jul 10, 2020·Prenatal Diagnosis·Sezen KislalAndrea G Edlow
Jan 9, 2019·Frontiers in Neuroscience·Md Habibur RahmanKyoungho Suk
Jun 11, 2019·Journal of Neuroendocrinology·Alejandra Freire-RegatilloJulie A Chowen
Apr 19, 2019·Endocrinology·Kristina HubbardKathleen G Mountjoy
Mar 27, 2021·Mechanisms of Ageing and Development·Julie A Chowen, Luis M Garcia-Segura
Apr 4, 2021·International Journal of Molecular Sciences·Irina V MilanovaChun-Xia Yi
Jun 3, 2021·International Journal of Molecular Sciences·Stéphane LéonCarmelo Quarta

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