The hypothesis that SARS-CoV-2 affects male reproductive ability by regulating autophagy.

Medical Hypotheses
Jun Sun

Abstract

The outbreak of CoronaVirus Disease19 (COVID19) in December 2019 posed a serious threat to public safety, and its rapid spread caused a global health emergency. Clinical data show that in addition to respiratory system damage, some male patients with COVID-19 are also accompanied by abnormal renal function and even renal damage. As the main receptor of syndrome coronavirus 2 (SARS-CoV-2), angiotensin converting enzyme 2 (ACE2) is also found to be highly expressed not only in respiratory mucosa and alveolar epithelial cells, but also in renal tubule cells, testicular Leydig cells and seminiferous tubule cells. This suggests that SARS-CoV-2 has the possibility of infecting the male reproductive system, and the recent detection of SARS-CoV-2 in the patient's semen further confirms this theory. In previous studies, it has been found that ACE2 has the ability to regulate autophagy. Not only that, recent studies have also found that SARS-CoV-2 infection can also lead to a reduction in autophagy. All of these associate SARS-CoV-2 with autophagy. Furthermore, autophagy has been shown to have an effect on male reproduction in many studies. Based on these, we propose the hypothesis that SARS-CoV-2 affects male reproductive function by re...Continue Reading

References

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Citations

Nov 18, 2020·Journal of Medical Virology·Cemile Merve Seymen
Jan 20, 2021·Open Biology·Shubhadeep RoychoudhuryPetr Slama
Jan 12, 2021·Andrology·Yangcheng YaoYufeng Li
Feb 10, 2021·Journal of Medical Virology·C Merve Seymen
May 13, 2021·Journal of Assisted Reproduction and Genetics·Mojgan MoshrefiMohammad Ali Khalili
Jul 3, 2021·International Journal of Environmental Research and Public Health·Luigi MontanoMarina Piscopo

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Methods Mentioned

BETA
biopsies

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