The hypoxia challenge test does not accurately predict hypoxia in flight in ex-preterm neonates

Chest
Steven M ResnickMary J Sharp

Abstract

Air travel may pose risks to ex-preterm neonates due to the low oxygen environment encountered during flights. We aimed to study the utility of the preflight hypoxia challenge test (HCT) to detect in-flight hypoxia in such infants. Ex-preterm (gestation < or = 35 completed weeks) infants ready for air transfer from the intensive/special care nursery to regional hospitals were studied. A pretransfer HCT was performed by exposing infants to 14% oxygen for 20 min. Failure was defined as a sustained fall in pulse oxygen saturation (Spo(2)) < or = 85%. A nurse blinded to the test result monitored the in-flight oxygen saturations in each infant. If Spo(2) fell to < or = 85%, oxygen was administered. Forty-six infants with median gestation of 32.2 weeks (range, 24 to 35.6 weeks) and birth weight of 1,667 g (range, 655 to 2,815 g) were recruited. No infants were receiving supplemental oxygen at the time of transfer. The HCT was performed at a median corrected age of 35.8 weeks (range, 33.1 to 43 weeks). Thirty-five infants (76%) passed the test, and the remainder failed. During the flight, 16 infants met the criteria for in-flight oxygen, but 12 of these infants (75%) had passed the preflight HCT. Of the 11 infants who failed the HCT, ...Continue Reading

References

Dec 1, 1993·The Journal of Pediatrics·D RichardD P Southall
Jan 1, 1994·BMJ : British Medical Journal·P J OadesA Bush
Feb 1, 1996·Thorax·D CramerD Geddes
Jun 17, 1998·The Journal of Pediatrics·R J MartinT E Dick
Mar 30, 2002·Thorax·UNKNOWN British Thoracic Society Standards of Care Committee
Apr 26, 2002·Pediatric Emergency Care·Andy P LeeNatalie L Relles
Jul 11, 2003·Respiratory Physiology & Neurobiology·Peter M ParslowRosemary S C Horne
Apr 23, 2004·Archives of Disease in Childhood·M P Samuels
May 7, 2005·Respiratory Physiology & Neurobiology·Rosemary S C HorneRichard Harding
Feb 21, 2007·Journal of Sleep Research·Heidi L RichardsonRosemary S C Horne
Mar 3, 2007·Thorax·G L HallS M Stick

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Citations

Jul 3, 2013·Archives of Disease in Childhood·Helene Elgaard KobbernagelBirgitte Hanel
Feb 22, 2012·Journal of Perinatology : Official Journal of the California Perinatal Association·J R Britton
Oct 16, 2014·The New England Journal of Medicine·Ruth M LöllgenAndrew Berry
Oct 23, 2012·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·A BoslandJ-C Dubus
Apr 7, 2012·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·G AubertinUNKNOWN Le Groupe de recherche sur les avancées en pneumologie pédiatrique (GRAPP)
Oct 25, 2011·Paediatric Respiratory Reviews·Adelaide WithersGraham L Hall
Mar 25, 2011·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·B Osona Rodríguez de TorresUNKNOWN Grupo de Trabajo de Técnicas de la Sociedad Española de Neumología Pediátrica
Dec 10, 2013·Revue des maladies respiratoires·G AubertinUNKNOWN Le Groupe de recherche sur les avancées en pneumologie pédiatrique (GRAPP)
Jul 23, 2013·Thorax·Mansi KhannaGraham L Hall
Jul 19, 2016·Paediatric Respiratory Reviews·Ian M Balfour-Lynn
Feb 27, 2018·European Journal of Pediatrics·Joël IsraëlsMarc van Heerde
Feb 23, 2019·American Journal of Respiratory and Critical Care Medicine·Jenny SvedenkransJ Jane Pillow
Jun 5, 2013·Primary Care Respiratory Journal : Journal of the General Practice Airways Group·Lynn K JosephsUNKNOWN British Thoracic Society
Oct 4, 2020·International Journal of Cardiology·Yoshihito MorimotoMichikazu Nakai

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