The hypoxic epicardial and subepicardial microenvironment.

Journal of Cardiovascular Translational Research
Fatih KocabasHesham A Sadek

Abstract

Recent reports indicate that the adult mammalian heart is capable of limited, but measurable, cardiomyocyte turnover. While the lineage origin of the newly formed cardiomyocytes is not entirely understood, mounting evidence suggest that the epicardium and subepicardium may represent an important source of cardiac stem or progenitor cells. Stem cell niches are characterized by low oxygen tension, where stem cells preferentially utilize cytoplasmic glycolysis to meet their energy demands. However, it is unclear if the heart harbors similar hypoxic regions, or whether these regions house metabolically distinct cardiac progenitor populations. Here we identify the epicardium and subepicardium as the cardiac hypoxic niche based on [corrected] capillary density quantification, and localization of Hif-1α in the uninjured heart. We further demonstrate that this hypoxic microenvironment houses a metabolically distinct population of glycolytic progenitor cells. Finally, we show that Hif-1α regulates the glycolytic phenotype and progenitor properties of these cells. These findings highlight important anatomical and functional properties of the epicardial and subepicardial microenvironment, and the potential role of hypoxia signaling in reg...Continue Reading

References

Sep 6, 2000·Proceedings of the National Academy of Sciences of the United States of America·T KamuraJ W Conaway
Apr 6, 2002·Circulation Research·Michael A LaflammeCharles E Murry
Sep 25, 2003·Cell·Antonio P BeltramiPiero Anversa
Oct 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hidemasa OhMichael D Schneider
Jan 2, 2004·The Journal of Biological Chemistry·Katsuhisa MatsuuraIssei Komuro
Feb 11, 2005·Nature·Karl-Ludwig LaugwitzKenneth R Chien
May 10, 2005·Experimental Cell Research·Maria Hägg, Stefan Wennström
Jun 7, 2006·Proceedings of the National Academy of Sciences of the United States of America·Konrad UrbanekAnnarosa Leri
Mar 22, 2007·Proceedings of the National Academy of Sciences of the United States of America·Kalindi ParmarJulian D Down
May 15, 2007·Annals of the New York Academy of Sciences·Nicola SmartPaul R Riley
Jul 17, 2007·Progress in Cardiovascular Diseases·Lucio BarileEduardo Marbán
Oct 11, 2007·Science's STKE : Signal Transduction Knowledge Environment·Gregg L Semenza
Oct 20, 2007·Circulation Research·Federica LimanaMaurizio C Capogrossi
Feb 22, 2008·Nature·Vincent F M Segers, Richard T Lee
Apr 10, 2008·Cell Stem Cell·Silvia Martin-PuigKenneth R Chien
May 16, 2008·Nature·Chen-Leng CaiSylvia M Evans
May 16, 2008·Nature·Robert PassierChristine L Mummery
Oct 24, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jianfei QiZe'ev Ronai
Dec 18, 2008·The Journal of Pathology·M R WalkerT S Stappenbeck
Apr 4, 2009·Science·Olaf BergmannJonas Frisén
Apr 23, 2009·Journal of Cellular and Molecular Medicine·L M PopescuMaria Simonetta Faussone-Pellegrini
Mar 20, 2010·Circulation Research·Harold E Olivey, Eric C Svensson
Jun 19, 2010·Journal of Cardiovascular Translational Research·Ana ArmiñánPilar Sepúlveda
Aug 5, 2010·Cell Stem Cell·Ahmed MohyeldinAlfredo Quiñones-Hinojosa
Apr 21, 2011·The Journal of Clinical Investigation·Bin ZhouWilliam T Pu
May 20, 2011·Nature·Michael A Laflamme, Charles E Murry
May 26, 2011·Neuron·Daisuke NakadaSean J Morrison
Dec 6, 2011·Cell Stem Cell·Igor I Slukvin
Dec 6, 2011·Cell Stem Cell·James J H ChongRichard P Harvey

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Citations

Mar 14, 2014·Cardiovascular Research·Serena Zacchigna, Mauro Giacca
Jul 8, 2014·Antioxidants & Redox Signaling·Wataru KimuraHesham A Sadek
Aug 21, 2012·Trends in Cardiovascular Medicine·Ahmed I Mahmoud, Enzo R Porrello
Oct 1, 2014·Stem Cell Research·Annarosa LeriPiero Anversa
May 7, 2015·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Antonia GermaniFederica Limana
Apr 21, 2016·Development·Maria Paola SantiniJason C Kovacic
Jul 25, 2017·Circulation·Gregory A Quaife-RyanEnzo R Porrello
Jul 22, 2017·Circulation Research·Xuejun Yuan, Thomas Braun
Mar 13, 2019·International Journal of Molecular Sciences·Cristina Mas-BarguesConsuelo Borrás
May 31, 2019·Stem Cells and Development·Kristina VukusicJoakim Sandstedt
Jan 13, 2018·Cell Death and Differentiation·Diego HerreroAntonio Bernad
Aug 10, 2020·Journal of Tissue Engineering and Regenerative Medicine·Humeyra SidalFatih Kocabas
Apr 14, 2018·Journal of Cardiovascular Development and Disease·Jiayi TaoDiana Ramírez-Bergeron
May 16, 2020·Scientific Reports·Raife Dilek TuranFatih Kocabas
Jun 15, 2017·Frontiers in Cardiovascular Medicine·Daniela CesselliAntonio Paolo Beltrami
Nov 20, 2018·F1000Research·Angeliqua SayedDavid Sassoon
Nov 20, 2020·Cells·Vagner O C RigaudMohsin Khan
Apr 30, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Julia HesseJürgen Schrader
Jun 9, 2021·Journal of Cellular Physiology·Esra AlbayrakFatih Kocabas

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