PMID: 8607227Feb 1, 1996Paper

The Hytrin Community Assessment Trial study: a one-year study of terazosin versus placebo in the treatment of men with symptomatic benign prostatic hyperplasia. HYCAT Investigator Group

Urology
C G RoehrbornR J Padley

Abstract

To determine the clinical effectiveness and safety of alpha(1)-blockade therapy versus placebo in the treatment of men with moderate to severe symptoms of prostatism in a community-based population under usual care conditions. The Hytrin Community Assessment Trial is a prospective, placebo-controlled, randomized, double-blinded, 1-year clinical trial, conducted at 15 academic medical centers (regional sites) and 141 private urology practices (satellite sites). A total of 2084 men at least 55 years old with moderate to severe symptoms of benign prostatic hyperplasia (BPH) as determined by an American Urological Association (AUA) Symptom Score (AUA-SS) of 13 or more points and a bother score (AUA-BS) of 8 or more were enrolled. Randomized patients at regional sites were required to have a peak urinary flow rate less that 15 mL/s with voided volume of at least 150 mL. Treatment with terazosin was initiated with 1 mg daily for 3 days, followed by 2 mg daily for 25 days. Thereafter, patients were titrated stepwise to 5 or 10 mg if they failed to achieve a 35% or greater improvement in the AUA-SS. Primary outcome measures were AUA-SS, AUA-BS, BPH Impact Index (BII), disease-specific quality of life (QQL) score, and treatment failure ...Continue Reading

References

Aug 1, 1976·British Journal of Urology·M CaineS Perlberg
Oct 22, 1992·The New England Journal of Medicine·G J GormleyJ S Tenover
Jan 1, 1990·The Prostate. Supplement·M J Barry
Jan 1, 1993·Scandinavian Journal of Urology and Nephrology·M M ChristensenS E Husted

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Citations

Aug 1, 2002·Current Urology Reports·Kevin T McVary
Jul 3, 2009·Current Urology Reports·Kenneth S Poon, Kevin T McVary
Mar 26, 2004·European Urology·Michael MarbergerJean de la Rosette
Dec 7, 2000·Techniques in Urology·L WagrellA Mattiasson
Dec 26, 2001·Urology·B Akduman, E D Crawford
Jan 18, 2002·Urology·John W KusekUNKNOWN MTOPS Research Group
Apr 29, 1998·Comprehensive Therapy·L Kuritzky
Feb 23, 1999·The Urologic Clinics of North America·H L Holtgrewe
Mar 15, 2001·European Journal of Medicinal Chemistry·C O Kappe
Aug 11, 2000·Bioorganic & Medicinal Chemistry Letters·P G NantermetC Forray
Feb 14, 2002·Australian Family Physician
Jun 19, 2009·International Journal of Impotence Research·T A Skolarus, J T Wei
Jan 22, 2003·International Journal of Urology : Official Journal of the Japanese Urological Association·Osamu IshizukaShinichi Ohshima

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