PMID: 7032201Aug 1, 1981Paper

The Ibc protein fraction of group B streptococci: characterization of protein antigens extracted by HCL

Acta Pathologica Et Microbiologica Scandinavica. Section B, Microbiology
L Bevanger, J Iversen

Abstract

The Ibc protein fraction of group B streptococci was prepared by HCL extraction of the type Ic strains A909 and 335. The fraction from strain A909 contained two protein antigens (alpha A 909 and beta A909) that could be separated by ion-exchange chromatography and isoelectric focusing. The 335 extract contained the alpha (alpha 335)-but not the beta antigen. The alpha 335 antigen was purified by similar procedures. The beta A909 antigen had a molecular weight of several hundred thousands, was immunogenic in rabbits and dissociated into several polypeptides on SDS-PAGE. Polypeptides with sub-unit molecular weights corresponding to 70,000 daltons showed antigenic activity. The alpha 335 antigen had a molecular weight of approximately 75,000 daltons as judged from gel filtration and SDS-PAGE. The antigen was immunogenic in rabbits. In contrast, the alpha A909 antigen showed neither protein lines on SDS-PAGE, nor immunogenicity in rabbits. However, the two alpha antigens showed serological crossreactivity in tests with the anti-alpha 335 serum.

References

Feb 1, 1969·Journal of Bacteriology·H W Wilkinson, M D Moody
Nov 1, 1971·Infection and Immunity·H W Wilkinson, R G Eagon
Mar 31, 1934·The Journal of Experimental Medicine·R C Lancefield

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Citations

Sep 2, 2009·Microbiology and Molecular Biology Reviews : MMBR·Angela H NobbsHoward F Jenkinson

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