The identification and evaluation of ATP binding cassette systems in the intracellular bacterium Francisella tularensis

Research in Microbiology
Helen S AtkinsRichard W Titball

Abstract

Francisella tularensis is a facultative intracellular bacterium responsible for the disease tularemia. Analysis of the fully sequenced genome of the virulent F. tularensis strain SCHU S4 has led to the identification of twenty ATP binding cassette (ABC) systems, of which five appear to be non-functional. The fifteen complete systems comprise three importers, five exporters, four systems involved in non-transport processes, and three systems of unknown or ill-defined function. The number and classification of the ABC systems in F. tularensis is similar to that observed in other intracellular bacteria, indicating that some of these systems may be important for the intracellular lifestyle of these organisms. Among the ABC systems identified in the genome are systems that may be involved in the virulence of F. tularensis SCHU S4. Six ABC system proteins were evaluated as candidate vaccine antigens against tularemia, although none provided significant protection against F. tularensis. However, a greater understanding of these systems may lead to the development of countermeasures against F. tularensis.

References

Oct 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·P G Guilfoile, C R Hutchinson
Sep 1, 1997·Nucleic Acids Research·S F AltschulD J Lipman
Aug 28, 1998·Microbiology·Ben N FryBernard A M van der Zeijst
Jun 11, 1999·Molecular Microbiology·E DassaM H Saier
Dec 22, 1999·Biochimie·M C KielM C Ganoza
Feb 24, 2000·Nucleic Acids Research·T D ReadC M Fraser
Mar 30, 2001·The Journal of Biological Chemistry·W T DoerrlerC R Raetz
Jun 26, 2001·Research in Microbiology·J P Claverys
Sep 15, 2001·Antimicrobial Agents and Chemotherapy·M C Ganoza, M C Kiel
Feb 12, 2002·Bioinformatics·Christian E V Storm, Erik L L Sonnhammer
Oct 9, 2002·Current Protein & Peptide Science·Philippe BouigeElie Dassa
Oct 9, 2002·EMBO Reports·Tiemen van der Heide, Bert Poolman
Jan 30, 2003·The EMBO Journal·Laurence NachinFrédéric Barras
Mar 18, 2003·The Journal of Biological Chemistry·Jing Wu, Ronald W Woodard
Mar 22, 2003·Trends in Microbiology·Richard W TitballMats Forsman
Apr 22, 2003·Proceedings of the National Academy of Sciences of the United States of America·Rekha SeshadriJohn F Heidelberg
Aug 9, 2003·Molecular Plant-microbe Interactions : MPMI·Ioannis StergiopoulosMaarten A De Waard
Mar 3, 2004·Research in Microbiology·Marie-Françoise HulloIsabelle Martin-Verstraete
Sep 24, 2004·Research in Microbiology·Stefania SerinaAlessandra Polissi
Nov 24, 2004·Infection and Immunity·Helen S Garmory, Richard W Titball
Jan 11, 2005·Nature Genetics·Pär LarssonRichard W Titball
Apr 6, 2005·Research in Microbiology·David N HarlandRichard W Titball

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Citations

Aug 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Horacio GilDavid G Thanassi
Feb 12, 2014·Microbes and Infection·Monique Barel, Alain Charbit
Mar 3, 2009·Proteomics·Malgorzata KowalczewskaDidier Raoult
May 24, 2011·Journal of Proteomics·Jiri DreslerJiri Stulik
Sep 15, 2010·The Journal of Antimicrobial Chemotherapy·Brieuc GestinMax Maurin
Aug 22, 2013·The Journal of Antimicrobial Chemotherapy·Vivien SuteraMax Maurin
Dec 21, 2011·Infection and Immunity·Shipan DaiJohn S Gunn
Apr 1, 2008·Proteomics. Clinical Applications·Malgorzata KowalczewskaDidier Raoult
Sep 11, 2020·International Journal of Antimicrobial Agents·Vivien SuteraMax Maurin

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