The identification and localization of a human gene with sequence similarity to Polycomblike of Drosophila melanogaster

Genomics
M CoulsonR Saint

Abstract

The Drosophila Polycomb group (PcG) of genes is required for the epigenetic regulation of a number of important developmental genes, including the homeotic (Hox) genes. The members of this gene family encode proteins that do not share sequence similarity, implying that each plays a unique role in this epigenetic repression mechanism. Polycomblike (Pcl) was the second PcG gene to be identified. We report here the isolation and characterization of a human cDNA, termed PHF1, which encodes a protein with significant sequence similarity to Drosophila Polycomblike (PCL). The region of similarity between PHF1 and PCL includes the two PHD fingers (C4-H-C3 motif), the region between them, and sequences C-terminal to the PHD fingers. PHF1 and PCL are 34% identical over this 258-residue region. PHF1 was mapped to 6p21.3 by fluorescence in situ hybridization. While several genetic diseases that are likely to result from developmental abnormalities map to this region, PHF1 is not a clear candidate gene for any of them.

References

Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Feb 1, 1995·Trends in Biochemical Sciences·R AaslandA F Stewart
Jul 29, 1994·Cell·R Krumlauf
Aug 1, 1995·Trends in Genetics : TIG·R Paro
Oct 25, 1996·Science·G D SchulerT J Hudson
Apr 1, 1997·Current Opinion in Genetics & Development·V Pirrotta
Jul 1, 1991·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Joanie McKeon, Hugh Willet Brock

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Citations

Dec 19, 2007·Molecular and Cellular Biology·Ru CaoYi Zhang
Feb 21, 2008·Molecular and Cellular Biology·Kavitha SarmaDanny Reinberg
Jul 25, 2013·BMC Pharmacology & Toxicology·Shamol SahaDavid H Farb
Mar 23, 2011·Human Pathology·Sarah Chiang, Esther Oliva
Aug 30, 2008·Cancer Genetics and Cytogenetics·Ioannis PanagopoulosConstance A Griffin
Feb 11, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Hugh W Brock, Cynthia L Fisher
Jun 11, 2002·Biochemical and Biophysical Research Communications·R TrappeW Engel
Oct 2, 2014·The FEBS Journal·Pedro VizánLuciano Di Croce
Nov 2, 2013·Molecular Plant·Myriam Calonje
Jun 8, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·R L GendronH Paradis
Nov 3, 2016·Molecular & Cellular Proteomics : MCP·Giorgio OlivieroGerard Cagney
Nov 15, 2007·Cytogenetic and Genome Research·F Micci, S Heim
Apr 18, 2017·Acta Pharmacologica Sinica·Yi ShiH Eric Xu
Sep 26, 2001·The Journal of Biological Chemistry·S O'ConnellR S Jones
May 29, 2018·Nature Genetics·Matteo PerinoGert Jan C Veenstra
May 12, 2021·Cancer Genetics·Paul Chih-Hsueh ChenChin-Chen Pan

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