The identification and suppression of inherited neurodegeneration in Caenorhabditis elegans

doi:10.1038/345410a0

PMID: 2342572DOI: 10.1038/345410a0May 31, 1990

The identification and suppression of inherited neurodegeneration in Caenorhabditis elegans

Nature

Martin Chalfie, E Wolinsky

Abstract

The dominant mutation deg-1(u38) results in a toxic gene product that leads to the late-onset degeneration of a small number of neurons in the nematode Caenorhabditis elegans. Both intragenic and extragenic mutations as well as changes in wild-type gene dosage can delay or block the time of onset of the neuronal deaths. The deg-1 gene has been cloned and a partial complementary DNA reveals that the gene encodes a novel protein that may act as a membrane receptor. Because the late-onset loss of specific sets of neurons, often as a result of dominant mutations, is characteristic of several human neurodegenerative diseases, the analysis of the deg-1 gene and its suppressors may provide a means of understanding the mechanisms underlying some of these human diseases.

Citations

Touch sensation in Caenorhabditis elegans

Mar 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R K Herman

Spatial and dye correlation analysis of intracellular Ca2+ distribution

May 1, 1994·Journal of Bioluminescence and Chemiluminescence·S L Mironov, A Hermann

Molecular genetics of cell death in the nematode Caenorhabditis elegans

Nov 1, 1992·Journal of Neurobiology·Monica Driscoll

Touch receptor development and function in Caenorhabditis elegans

Oct 1, 1993·Journal of Neurobiology·Martin Chalfie

Touch sensitivity in Caenorhabditis elegans

Feb 8, 2007·Pflügers Archiv : European journal of physiology·Alexander Bounoutas, Martin Chalfie

Programmed cell death: implications for neuropsychiatric disorders

Jun 15, 1994·Biological Psychiatry·R L MargolisR M Post

Dose-related effects of cycloheximide on delayed neuronal death in the gerbil hippocampus after bilateral transitory forebrain ischemia

Jan 1, 1994·Journal of the Neurological Sciences·A TortosaI Ferrer

What causes motoneuron disease?

Dec 1, 1990·Lancet

Developmental and abnormal cell death in C. elegans

Jan 1, 1992·Trends in Neurosciences·Monica Driscoll, Martin Chalfie

Target dependence of motoneuronal survival: the current status

Dec 1, 1990·Neuroscience Research·M Kuno

Cell death and removal in the cerebral cortex during development

Jul 1, 1992·Progress in Neurobiology·I FerrerC Auladell

Genetic approaches to mechanosensory transduction

Aug 1, 1995·Current Opinion in Neurobiology·M Kernan, C Zuker

Nerve growth factor protects R2 cells against neurotoxicity induced by methamphetamine

Apr 20, 2004·Toxicology Letters·Jun-Lan ZhouChang-Ling Li

Tetraethylammonium block of the BNC1 channel

Feb 27, 1999·Biophysical Journal·C M AdamsM J Welsh

Molecular genetic approaches to the genes of longevity, aging and neurodegeneration in mammals

Nov 14, 1997·Mechanisms of Ageing and Development·N Mori

Amiloride-sensitive epithelial sodium channel subunits are expressed in human and mussel immunocytes

Mar 22, 2002·Developmental and Comparative Immunology·Enzo OttavianiI Hanukoglu

A supramolecular complex underlying touch sensitivity

Jul 1, 1996·Trends in Neurosciences·O P Hamill, D W McBride

C. elegans neuroscience: genetics to genome

Dec 29, 1998·Trends in Genetics : TIG·Martin Chalfie, E M Jorgensen

Apoptosis in development and disease of the nervous system: II. Apoptosis in childhood neurologic disease

Feb 1, 1997·Pediatric Neurology·H A GelbardN F Schor

Drosophila as a model to study human brain degenerative diseases

May 2, 2001·Parkinsonism & Related Disorders·K -T. Min

Calcium-dependent and aspartyl proteases in neurodegeneration and ageing in C. elegans

Oct 3, 2003·Ageing Research Reviews·Chrysanthi Samara, Nektarios Tavernarakis

Insights into the molecular determinants of proton inhibition in an acid-inactivated degenerins and mammalian epithelial Na(+) channel

Sep 23, 2009·Biochemistry·Ying Wang, Laura Bianchi

Noncanonical cell death programs in the nematode Caenorhabditis elegans

Apr 26, 2008·Cell Death and Differentiation·E S BlumShai Shaham

Mutant sodium channel for tumor therapy

Mar 5, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Bakhos A TannousXandra O Breakefield

Pore architecture and ion sites in acid-sensing ion channels and P2X receptors

Jul 31, 2009·Nature·Eric B GonzalesEric Gouaux

The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration

Dec 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Keiichi NagataJ García-Añoveros

Molecular cloning and analysis of small optic lobes, a structural brain gene of Drosophila melanogaster

Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S J DelaneyG L Miklos

Genetic interactions affecting touch sensitivity in Caenorhabditis elegans

Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·G GuMartin Chalfie

Pickpocket1 is an ionotropic molecular sensory transducer

Oct 4, 2012·The Journal of Biological Chemistry·Nina BoikoBenjamin A Eaton

Hyperactivation of the mammalian degenerin MDEG promotes caspase-8 activation and apoptosis

Dec 15, 2012·The Journal of Biological Chemistry·Ji-An PanWei-Xing Zong

Sequence and transmembrane topology of MEC-4, an ion channel subunit required for mechanotransduction in Caenorhabditis elegans

Jun 1, 1996·The Journal of Cell Biology·C C LaiMonica Driscoll

Gain-of-function mutations in the MEC-4 DEG/ENaC sensory mechanotransduction channel alter gating and drug blockade

Jan 31, 2007·The Journal of General Physiology·Austin L BrownMiriam B Goodman

MEC-2 and MEC-6 in the Caenorhabditis elegans sensory mechanotransduction complex: auxiliary subunits that enable channel activity

May 28, 2008·The Journal of General Physiology·Austin L BrownMiriam B Goodman

Asp433 in the closing gate of ASIC1 determines stability of the open state without changing properties of the selectivity filter or Ca2+ block

Mar 2, 2011·The Journal of General Physiology·Tianbo LiC M Canessa

Neurotoxic unc-8 mutants encode constitutively active DEG/ENaC channels that are blocked by divalent cations

Jul 31, 2013·The Journal of General Physiology·Ying WangLaura Bianchi

Death by necrosis. Uncontrollable catastrophe, or is there order behind the chaos?

Jul 9, 2002·EMBO Reports·Popi Syntichaki, Nektarios Tavernarakis

A mutation causing pseudohypoaldosteronism type 1 identifies a conserved glycine that is involved in the gating of the epithelial sodium channel

Mar 3, 1997·The EMBO Journal·S GründerB C Rossier

G protein hyperactivation of the Caenorhabditis elegans adenylyl cyclase SGS-1 induces neuronal degeneration

Sep 2, 1998·The EMBO Journal·H C KorswagenR H Plasterk

Exploration of the pore structure of a peptide-gated Na+ channel

Oct 13, 2001·The EMBO Journal·M PoëtL Counillon

A new member of the acid-sensing ion channel family

Aug 3, 2000·Neuroreport·A N AkopianJ N Wood

The Gene for Ciliary Neurotrophic Factor (CNTF) Maps to Murine Chromosome 19 and its Expression is Not Affected in the Hereditary Motoneuron Disease 'Wobbler' of the Mouse

Oct 1, 1991·The European Journal of Neuroscience·K KaupmannH Jockusch

Theories of neurodegeneration

May 11, 1992·Annals of the New York Academy of Sciences·D B CalneT Nygaard

Overview of Parkinson's disease

May 11, 1992·Annals of the New York Academy of Sciences·R C Duvoisin

Physiology and protein synthesis in programmed cell death. Early synthesis and DNA degradation

Nov 21, 1992·Annals of the New York Academy of Sciences·R A Lockshin, Z F Zakeri

Hereditary Lewy-body parkinsonism and evidence for a genetic etiology of Parkinson's disease

Oct 1, 1992·Brain Pathology·R C Duvoisin, W G Johnson

Eukaryotic mechanosensitive channels

Mar 3, 2010·Annual Review of Biophysics·Johanna Arnadottir, Martin Chalfie

The molecules of mechanosensation

Jan 1, 1997·Annual Review of Neuroscience·J García-Añoveros, D P Corey

Signal transduction in the Caenorhabditis elegans nervous system

Apr 8, 1998·Annual Review of Neuroscience·C I Bargmann, J M Kaplan

Molecular modeling of mechanotransduction in the nematode Caenorhabditis elegans

Jan 1, 1997·Annual Review of Physiology·Nektarios Tavernarakis, Monica Driscoll

Structure and regulation of amiloride-sensitive sodium channels

Jun 9, 2000·Annual Review of Physiology·D Alvarez de la RosaP Zhang

Transducing touch in Caenorhabditis elegans

Jan 14, 2003·Annual Review of Physiology·Miriam B Goodman, Erich M Schwarz

Structure and activity of the acid-sensing ion channels

Jul 31, 2012·American Journal of Physiology. Cell Physiology·Thomas W SherwoodCandice C Askwith

Knockout of glial channel ACD-1 exacerbates sensory deficits in a C. elegans mutant by regulating calcium levels of sensory neurons

Oct 14, 2011·Journal of Neurophysiology·Ying WangLaura Bianchi

The C. elegans EMAP-like protein, ELP-1 is required for touch sensation and associates with microtubules and adhesion complexes

Nov 19, 2008·BMC Developmental Biology·Jennifer L HuestonKathy A Suprenant

The cell biology of autophagy in metazoans: a developing story

Jun 24, 2008·Development·Alicia Meléndez, Thomas P Neufeld

MRG-1, an autosome-associated protein, silences X-linked genes and protects germline immortality in Caenorhabditis elegans

Jan 12, 2007·Development·Teruaki TakasakiSusan Strome

Diapause formation and downregulation of insulin-like signaling via DAF-16/FOXO delays axonal degeneration and neuronal loss

Jan 10, 2013·PLoS Genetics·Andrea CalixtoFelipe A Court

Temperature- and touch-sensitive neurons couple CNG and TRPV channel activities to control heat avoidance in Caenorhabditis elegans

Mar 27, 2012·PloS One·Shu LiuRalf Baumeister

The genetics of Parkinson's disease

Jan 1, 1993·Reviews in the Neurosciences·L I Golbe

The DEG/ENaC protein MEC-10 regulates the transduction channel complex in Caenorhabditis elegans touch receptor neurons

Sep 2, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Johanna ArnadottirMartin Chalfie

Caenorhabditis elegans genes required for the engulfment of apoptotic corpses function in the cytotoxic cell deaths induced by mutations in lin-24 and lin-33

May 7, 2008·Genetics·Brendan D GalvinH Robert Horvitz

Molecular cloning and characterization of mammalian homologues of the Drosophila retinal degeneration B gene

Jul 30, 1997·Biochemical and Biophysical Research Communications·Y AikawaT Watanabe

Genetically targeted cell disruption in Caenorhabditis elegans

Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·S HarbinderMonica Driscoll

BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels

Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·J García-AñoverosD P Corey

An ion channel of the degenerin/epithelial sodium channel superfamily controls the defecation rhythm in Caenorhabditis elegans

Sep 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·M Take-UchiI Katsura

Two functionally dependent acetylcholine subunits are encoded in a single Caenorhabditis elegans operon

Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·M TreininMartin Chalfie

The alpha subunit of the epithelial sodium channel in the mouse: developmental regulation of its expression

Sep 1, 1997·Pediatric Research·A DagenaisY Berthiaume

A specific subset of transient receptor potential vanilloid-type channel subunits in Caenorhabditis elegans endocrine cells function as mixed heteromers to promote neurotransmitter release

Oct 24, 2006·Genetics·Antony M JoseMichael R Koelle

Insight into DEG/ENaC channel gating from genetics and structure

Oct 3, 2012·Physiology·Amy L Eastwood, Miriam B Goodman

The latent membrane protein-1 in Epstein-Barr virus-transformed lymphoblastoid cells is found with ubiquitin-protein conjugates and heat-shock protein 70 in lysosomes oriented around the microtubule organizing centre

Jul 1, 1991·The Journal of Pathology·L LászlóR J Mayer

Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans

Nov 1, 2002·Nature·Popi SyntichakiNektarios Tavernarakis

The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel

Dec 13, 2002·Nature·Dattananda S ChelurMartin Chalfie

Cloning of the amiloride-sensitive FMRFamide peptide-gated sodium channel

Dec 14, 1995·Nature·E LinguegliaP Barbry

The neurotoxic MEC-4(d) DEG/ENaC sodium channel conducts calcium: implications for necrosis initiation

Nov 16, 2004·Nature Neuroscience·Laura BianchiMonica Driscoll

Ripped pocket and pickpocket, novel Drosophila DEG/ENaC subunits expressed in early development and in mechanosensory neurons

Feb 14, 1998·The Journal of Cell Biology·C M AdamsM J Welsh

Proteolytic mechanisms in necrotic cell death and neurodegeneration

Jun 10, 2005·FEBS Letters·Marta Artal-Sanz, Nektarios Tavernarakis

Patch clamp study of the UNC-105 degenerin and its interaction with the LET-2 collagen in Caenorhabditis elegans muscle

Mar 17, 2004·The Journal of Physiology·Maëlle JospinBruno Allard

Molecular cloning, functional expression and chromosomal localization of an amiloride-sensitive Na(+) channel from human small intestine

Apr 18, 2000·FEBS Letters·L SchaeferE Lingueglia

Functional domains within the degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels

Nov 2, 1999·The Journal of Physiology·D J Benos, B A Stanton

Cloning and functional expression of a novel degenerin-like Na+ channel gene in mammals

Aug 24, 1999·The Journal of Physiology·H SakaiM Lazdunski

What is the hair cell transduction channel?

Aug 12, 2006·The Journal of Physiology·D P Corey

How are necrotic cells recognized by their predators?

Apr 14, 2016·Worm·Zao Li, Zheng Zhou

The ameliorative and toxic effects of selenite on Caenorhabditis elegans

Dec 15, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Wen-Hsuan LiVivian Hsiu-Chuan Liao

Neurodegenerative disorders: insights from the nematode Caenorhabditis elegans

May 25, 2010·Neurobiology of Disease·Maria Dimitriadi, Anne C Hart

Non-developmentally programmed cell death in Caenorhabditis elegans

Jan 2, 2007·Seminars in Cancer Biology·Nikos Kourtis, Nektarios Tavernarakis

Loss of calbindin-D28K is associated with the full range of tangle pathology within basal forebrain cholinergic neurons in Alzheimer's disease

Sep 30, 2015·Neurobiology of Aging·Saman S AhmadianChangiz Geula

Invertebrate nociception: behaviors, neurons and molecules

Sep 14, 2004·Journal of Neurobiology·David M Tobin, C I Bargmann

Non-apoptotic cell death in Caenorhabditis elegans

Jan 29, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Manolis Vlachos, Nektarios Tavernarakis

Clearance of apoptotic cells in Caenorhabditis elegans

Mar 31, 2005·Seminars in Cell & Developmental Biology·Paolo M Mangahas, Zheng Zhou

Wobbler, a mutation affecting motoneuron survival and gonadal functions in the mouse, maps to proximal chromosome 11

May 1, 1992·Genomics·K KaupmannH Jockusch

Extracellular trypsin increases ASIC1a selectivity for monovalent versus divalent cations

May 25, 2005·Journal of Neuroscience Methods·Emil NeagaMaria-Luiza Flonta

Neurodegenerative conditions associated with ageing: a molecular interplay?

Dec 22, 2004·Mechanisms of Ageing and Development·Kostoula Troulinaki, Nektarios Tavernarakis

Death from natural and unnatural causes

Dec 1, 1991·Current Biology : CB·C I Bargmann

The effect of cycloheximide on natural and X-ray-induced cell death in the developing cerebral cortex

Aug 21, 1992·Brain Research·I Ferrer

Sensory systems: their impact on C. elegans survival

Jul 6, 2014·Neuroscience·E N AllenJ Alcedo

Caenorhabditis elegans paraoxonase-like proteins control the functional expression of DEG/ENaC mechanosensory proteins

Mar 5, 2016·Molecular Biology of the Cell·Yushu ChenMartin Chalfie

Genetics of sensory mechanotransduction

Nov 14, 2002·Annual Review of Genetics·Glen G Ernstrom, Martin Chalfie

H(+)-gated cation channels: neuronal acid sensors in the NaC/DEG family of ion channels

Aug 4, 1998·Current Opinion in Neurobiology·R Waldmann, M Lazdunski

Editorial

Apr 7, 2015·Neuropharmacology·M Lazdunski

Mechanosensation circuitry in Caenorhabditis elegans: A focus on gentle touch

Dec 30, 2014·Peptides·Jason C CampbellWilliam G Bendena

Contribution of Drosophila DEG/ENaC genes to salt taste

Jul 10, 2003·Neuron·Lei LiuM J Welsh

unc-8, a DEG/ENaC family member, encodes a subunit of a candidate mechanically gated channel that modulates C. elegans locomotion

Jan 1, 1997·Neuron·Nektarios TavernarakisMonica Driscoll

Necrotic cell death in C. elegans requires the function of calreticulin and regulators of Ca(2+) release from the endoplasmic reticulum

Oct 3, 2001·Neuron·K XuMonica Driscoll

The nematode degenerin UNC-105 forms ion channels that are activated by degeneration- or hypercontraction-causing mutations

Jul 9, 1998·Neuron·J García-AñoverosD P Corey

Pickpocket is a DEG/ENaC protein required for mechanical nociception in Drosophila larvae

Feb 23, 2010·Current Biology : CB·Lixian ZhongW Daniel Tracey

Regulation of Caenorhabditis elegans degenerin proteins by a putative extracellular domain

Apr 1, 1995·Current Biology : CB·J García-AñoverosMartin Chalfie

A molecular component of the arterial baroreceptor mechanotransducer

Jan 12, 1999·Neuron·H A DrummondF M Abboud

DEG/ENaCs lead by a nose: mechanotransduction in a polymodal sensory neuron

Sep 10, 2011·Neuron·Aislyn M NelsonEllen A Lumpkin

DEG/ENaC but not TRP channels are the major mechanoelectrical transduction channels in a C. elegans nociceptor

Sep 10, 2011·Neuron·Shana L GeffeneyMiriam B Goodman

Extracellular proteins needed for C. elegans mechanosensation

Jan 1, 1996·Neuron·H DuMartin Chalfie

MEC-2 is recruited to the putative mechanosensory complex in C. elegans touch receptor neurons through its stomatin-like domain

Nov 9, 2004·Current Biology : CB·Shifang ZhangMartin Chalfie

An intracellular serpin regulates necrosis by inhibiting the induction and sequelae of lysosomal injury

Sep 25, 2007·Cell·Cliff J LukeGary A Silverman

A mutated acetylcholine receptor subunit causes neuronal degeneration in C. elegans

Apr 1, 1995·Neuron·M Treinin, Martin Chalfie

Developmental timing of a sensory-mediated larval surfacing behavior correlates with cessation of feeding and determination of final adult size

Jul 16, 2010·Developmental Biology·Lauren J WegmanWayne A Johnson

Hox Genes Promote Neuronal Subtype Diversification through Posterior Induction in Caenorhabditis elegans

Nov 6, 2015·Neuron·Chaogu ZhengMartin Chalfie

Expression cloning of the epithelial sodium channel

Oct 1, 1995·Kidney International·C M CanessaB C Rossier

DEG/ENaC channels: a touchy superfamily that watches its salt

Sep 3, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·I Mano, Monica Driscoll

The pre-transmembrane 1 domain of acid-sensing ion channels participates in the ion pore

Apr 3, 1999·The Journal of Biological Chemistry·S CoscoyM Lazdunski

Pseudohypoaldosteronism type 1 and Liddle's syndrome mutations that affect the single-channel properties of the epithelial Na+ channel

Nov 6, 2015·Physiological Reports·Nina BoikoJames D Stockand

Ca2+ permeability and Na+ conductance in cellular toxicity caused by hyperactive DEG/ENaC channels

Oct 21, 2016·American Journal of Physiology. Cell Physiology·Cristina MatthewmanLaura Bianchi

Genetic models of mechanotransduction: the nematode Caenorhabditis elegans

Sep 24, 2004·Physiological Reviews·Popi Syntichaki, Nektarios Tavernarakis

The synaptic action of Degenerin/Epithelial sodium channels

Jul 13, 2018·Channels·Alexis S Hill, Yehuda Ben-Shahar

Structure of the human epithelial sodium channel by cryo-electron microscopy

Sep 26, 2018·ELife·Sigrid NorengIsabelle Baconguis

Neurobiology. Nematodes in nervous decline

Feb 14, 1991·Nature·J Hodgkin

The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration

Feb 14, 1991·Nature·Monica Driscoll, Martin Chalfie

Degenerin similarities

Feb 11, 1993·Nature·Martin ChalfieM Huang

Epithelial sodium channel related to proteins involved in neurodegeneration

Feb 4, 1993·Nature·C M CanessaB C Rossier

Uncoupling of hypomyelination and glial cell death by a mutation in the proteolipid protein gene

Aug 27, 1992·Nature·A SchneiderK A Nave

Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1

Mar 1, 1996·Nature Genetics·S S ChangR P Lifton

Trinity of cation channels

Feb 3, 1994·Nature·T J Jentsch

Gene interactions affecting mechanosensory transduction in Caenorhabditis elegans

Feb 3, 1994·Nature·M Huang, Martin Chalfie

A transmembrane domain of the putative channel subunit MEC-4 influences mechanotransduction and neurodegeneration in C. elegans

Feb 3, 1994·Nature·K Hong, Monica Driscoll

Mechanosensory signalling in C. elegans mediated by the GLR-1 glutamate receptor

Nov 2, 1995·Nature·A V MaricqC I Bargmann

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

Jun 29, 1995·Nature·R SherringtonP H St George-Hyslop

Vascular ENaC proteins are required for renal myogenic constriction

May 26, 2005·American Journal of Physiology. Renal Physiology·Nikki L Jernigan, H A Drummond

The biochemistry of neuronal necrosis: rogue biology?

Aug 2, 2003·Nature Reviews. Neuroscience·Popi Syntichaki, Nektarios Tavernarakis

Acid-sensing ion channel (ASIC) 4 gene: physical mapping, genomic organisation, and evaluation as a candidate for paroxysmal dystonia

Sep 26, 2001·European Journal of Human Genetics : EJHG·S GründerJ K Fink

A common set of engulfment genes mediates removal of both apoptotic and necrotic cell corpses in C. elegans

Jan 9, 2001·Nature Cell Biology·S ChungMonica Driscoll

Multimodal sensory processing in Caenorhabditis elegans

Jun 22, 2018·Open Biology·Athanasios MetaxakisNektarios Tavernarakis

Functional features of the "finger" domain of the DEG/ENaC channels MEC-4 and UNC-8

Apr 26, 2018·American Journal of Physiology. Cell Physiology·Cristina MatthewmanLaura Bianchi

The Role of Ca2+ Signaling in Aging and Neurodegeneration: Insights from Caenorhabditis elegans Models

Jan 18, 2020·Cells·Javier AlvarezMayte Montero

Molecular cloning and functional expression of a novel amiloride-sensitive Na+ channel

Nov 17, 1995·The Journal of Biological Chemistry·R WaldmannM Lazdunski

Functional degenerin-containing chimeras identify residues essential for amiloride-sensitive Na+ channel function

May 19, 1995·The Journal of Biological Chemistry·R WaldmannM Lazdunski

Assembly of the epithelial Na+ channel evaluated using sucrose gradient sedimentation analysis

Aug 26, 1998·The Journal of Biological Chemistry·C ChengM J Welsh

The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans

May 3, 1996·The Journal of Biological Chemistry·R WaldmannM Lazdunski

Mutations causing neurodegeneration in Caenorhabditis elegans drastically alter the pH sensitivity and inactivation of the mammalian H+-gated Na+ channel MDEG1

Jun 23, 1998·The Journal of Biological Chemistry·G ChampignyM Lazdunski

pH alterations "reset" Ca2+ sensitivity of brain Na+ channel 2, a degenerin/epithelial Na+ ion channel, in planar lipid bilayers

Aug 22, 2001·The Journal of Biological Chemistry·B K BerdievD J Benos

Interactions between subunits of the human epithelial sodium channel

Oct 27, 1997·The Journal of Biological Chemistry·C M AdamsM J Welsh

Cloning and expression of a novel human brain Na+ channel

Apr 5, 1996·The Journal of Biological Chemistry·M P PriceM J Welsh

The acid-sensitive ionic channel subunit ASIC and the mammalian degenerin MDEG form a heteromultimeric H+-gated Na+ channel with novel properties

Nov 20, 1997·The Journal of Biological Chemistry·F BassilanaM Lazdunski

Phylogenetic characterization of the epithelial Na+ channel (ENaC) family

Jul 1, 1996·Molecular Membrane Biology·T Le, M H Saier

From genes to integrative physiology: ion channel and transporter biology in Caenorhabditis elegans

Mar 29, 2003·Physiological Reviews·Kevin Strange

Oxidative stress, autophagy and airway ion transport

Oct 12, 2018·American Journal of Physiology. Cell Physiology·Scott M O'Grady

Molecular cloning of a non-inactivating proton-gated Na+ channel specific for sensory neurons

Aug 22, 1997·The Journal of Biological Chemistry·R WaldmannM Lazdunski

Maitotoxin and P2Z/P2X(7) purinergic receptor stimulation activate a common cytolytic pore

Oct 12, 1999·The American Journal of Physiology·W P SchillingW G Sinkins

Rabbit retinal neurons and glia express a variety of ENaC/DEG subunits

Jun 11, 2002·American Journal of Physiology. Cell Physiology·L M BrockwayK T Keyser

Protons activate brain Na+ channel 1 by inducing a conformational change that exposes a residue associated with neurodegeneration

Nov 7, 1998·The Journal of Biological Chemistry·C M AdamsM J Welsh

H(+)-gated cation channels

Jul 22, 1999·Annals of the New York Academy of Sciences·R WaldmannM Lazdunski

MEC-10 and MEC-19 Reduce the Neurotoxicity of the MEC-4(d) DEG/ENaC Channel in Caenorhabditis elegans

May 14, 2016·G3 : Genes - Genomes - Genetics·Yushu ChenMartin Chalfie

Activation of the Caenorhabditis elegans Degenerin Channel by Shear Stress Requires the MEC-10 Subunit

May 18, 2016·The Journal of Biological Chemistry·Shujie ShiThomas R Kleyman

Immunology of apoptosis and necrosis

Jan 19, 2006·Biochemistry. Biokhimii︠a︡·S Ya ProskuryakovA I Kolesnikova

A glial DEG/ENaC channel functions with neuronal channel DEG-1 to mediate specific sensory functions in C. elegans

Aug 15, 2008·The EMBO Journal·Ying WangLaura Bianchi

Activation of the Human Epithelial Sodium Channel (ENaC) by Bile Acids Involves the Degenerin Site

Aug 5, 2016·The Journal of Biological Chemistry·Alexandr V IlyaskinSilke Haerteis

Dopamine signaling tunes spatial pattern selectivity in C. elegans

Mar 30, 2017·ELife·Bicheng HanJihong Bai

The mechanoreceptor DEG-1 regulates cold tolerance in Caenorhabditis elegans

Feb 5, 2020·EMBO Reports·Natsune TakagakiAtsushi Kuhara

Sensory cilia as the Achilles heel of nematodes when attacked by carnivorous mushrooms

Mar 4, 2020·Proceedings of the National Academy of Sciences of the United States of America·Ching-Han LeeYen-Ping Hsueh

Studying human neurodegenerative diseases in flies and worms

Nov 18, 2000·Journal of Neuropathology and Experimental Neurology·M B Feany

ENaC subunits are molecular components of the arterial baroreceptor complex

Jul 19, 2001·Annals of the New York Academy of Sciences·H A DrummondF M Abboud

Diapause induces functional axonal regeneration after necrotic insult in C. elegans

Jan 15, 2019·PLoS Genetics·Mauricio CaneoAndrea Calixto

Bacterially produced metabolites protect C. elegans neurons from degeneration

Mar 26, 2020·PLoS Biology·Arles UrrutiaAndrea Calixto

The Phe-Met-Arg-Phe-amide-activated sodium channel is a tetramer

May 9, 1998·The Journal of Biological Chemistry·S CoscoyP Barbry

1990 Richardson Lecture. Challenges for neurology in the nineties: will we survive?

Feb 1, 1991·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·J B Martin

Related Concepts

Caenorhabditis

Cistron

Genetic Conditions, Dominant

Cell Surface Proteins

Nerve Degeneration

Suppressor Mutation

Gene Expression

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.