The identification and suppression of inherited neurodegeneration in Caenorhabditis elegans

Nature
Martin Chalfie, E Wolinsky

Abstract

The dominant mutation deg-1(u38) results in a toxic gene product that leads to the late-onset degeneration of a small number of neurons in the nematode Caenorhabditis elegans. Both intragenic and extragenic mutations as well as changes in wild-type gene dosage can delay or block the time of onset of the neuronal deaths. The deg-1 gene has been cloned and a partial complementary DNA reveals that the gene encodes a novel protein that may act as a membrane receptor. Because the late-onset loss of specific sets of neurons, often as a result of dominant mutations, is characteristic of several human neurodegenerative diseases, the analysis of the deg-1 gene and its suppressors may provide a means of understanding the mechanisms underlying some of these human diseases.

Citations

Mar 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R K Herman
May 1, 1994·Journal of Bioluminescence and Chemiluminescence·S L Mironov, A Hermann
Nov 1, 1992·Journal of Neurobiology·Monica Driscoll
Oct 1, 1993·Journal of Neurobiology·Martin Chalfie
Feb 8, 2007·Pflügers Archiv : European journal of physiology·Alexander Bounoutas, Martin Chalfie
Jun 15, 1994·Biological Psychiatry·R L MargolisR M Post
Jan 1, 1992·Trends in Neurosciences·Monica Driscoll, Martin Chalfie
Dec 1, 1990·Neuroscience Research·M Kuno
Jul 1, 1992·Progress in Neurobiology·I FerrerC Auladell
Aug 1, 1995·Current Opinion in Neurobiology·M Kernan, C Zuker
Apr 20, 2004·Toxicology Letters·Jun-Lan ZhouChang-Ling Li
Feb 27, 1999·Biophysical Journal·C M AdamsM J Welsh
Mar 22, 2002·Developmental and Comparative Immunology·Enzo OttavianiI Hanukoglu
Jul 1, 1996·Trends in Neurosciences·O P Hamill, D W McBride
Dec 29, 1998·Trends in Genetics : TIG·Martin Chalfie, E M Jorgensen
May 2, 2001·Parkinsonism & Related Disorders·K -T. Min
Oct 3, 2003·Ageing Research Reviews·Chrysanthi Samara, Nektarios Tavernarakis
Apr 26, 2008·Cell Death and Differentiation·E S BlumShai Shaham
Mar 5, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Bakhos A TannousXandra O Breakefield
Dec 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Keiichi NagataJ García-Añoveros
Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S J DelaneyG L Miklos
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·G GuMartin Chalfie
Oct 4, 2012·The Journal of Biological Chemistry·Nina BoikoBenjamin A Eaton
Dec 15, 2012·The Journal of Biological Chemistry·Ji-An PanWei-Xing Zong
Jan 31, 2007·The Journal of General Physiology·Austin L BrownMiriam B Goodman
Jul 9, 2002·EMBO Reports·Popi Syntichaki, Nektarios Tavernarakis
Oct 13, 2001·The EMBO Journal·M PoëtL Counillon
Aug 3, 2000·Neuroreport·A N AkopianJ N Wood
May 11, 1992·Annals of the New York Academy of Sciences·D B CalneT Nygaard
May 11, 1992·Annals of the New York Academy of Sciences·R C Duvoisin
Nov 21, 1992·Annals of the New York Academy of Sciences·R A Lockshin, Z F Zakeri
Mar 3, 2010·Annual Review of Biophysics·Johanna Arnadottir, Martin Chalfie
Jan 1, 1997·Annual Review of Neuroscience·J García-Añoveros, D P Corey
Apr 8, 1998·Annual Review of Neuroscience·C I Bargmann, J M Kaplan
Jan 1, 1997·Annual Review of Physiology·Nektarios Tavernarakis, Monica Driscoll
Jun 9, 2000·Annual Review of Physiology·D Alvarez de la RosaP Zhang
Jan 14, 2003·Annual Review of Physiology·Miriam B Goodman, Erich M Schwarz
Jul 31, 2012·American Journal of Physiology. Cell Physiology·Thomas W SherwoodCandice C Askwith
Jun 24, 2008·Development·Alicia Meléndez, Thomas P Neufeld
Jan 1, 1993·Reviews in the Neurosciences·L I Golbe
Sep 2, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Johanna ArnadottirMartin Chalfie
Jul 30, 1997·Biochemical and Biophysical Research Communications·Y AikawaT Watanabe
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·S HarbinderMonica Driscoll
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·J García-AñoverosD P Corey
Sep 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·M Take-UchiI Katsura
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·M TreininMartin Chalfie
Oct 3, 2012·Physiology·Amy L Eastwood, Miriam B Goodman
Jun 10, 2005·FEBS Letters·Marta Artal-Sanz, Nektarios Tavernarakis
Aug 24, 1999·The Journal of Physiology·H SakaiM Lazdunski
Aug 12, 2006·The Journal of Physiology·D P Corey
Apr 14, 2016·Worm·Zao Li, Zheng Zhou
Dec 15, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Wen-Hsuan LiVivian Hsiu-Chuan Liao
May 25, 2010·Neurobiology of Disease·Maria Dimitriadi, Anne C Hart
Jan 2, 2007·Seminars in Cancer Biology·Nikos Kourtis, Nektarios Tavernarakis
Sep 14, 2004·Journal of Neurobiology·David M Tobin, C I Bargmann
Jan 29, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Manolis Vlachos, Nektarios Tavernarakis
Mar 31, 2005·Seminars in Cell & Developmental Biology·Paolo M Mangahas, Zheng Zhou
May 25, 2005·Journal of Neuroscience Methods·Emil NeagaMaria-Luiza Flonta
Dec 22, 2004·Mechanisms of Ageing and Development·Kostoula Troulinaki, Nektarios Tavernarakis
Dec 1, 1991·Current Biology : CB·C I Bargmann
Jul 6, 2014·Neuroscience·E N AllenJ Alcedo
Nov 14, 2002·Annual Review of Genetics·Glen G Ernstrom, Martin Chalfie
Aug 4, 1998·Current Opinion in Neurobiology·R Waldmann, M Lazdunski
Apr 7, 2015·Neuropharmacology·M Lazdunski
Dec 30, 2014·Peptides·Jason C CampbellWilliam G Bendena
Jul 10, 2003·Neuron·Lei LiuM J Welsh
Feb 23, 2010·Current Biology : CB·Lixian ZhongW Daniel Tracey
Apr 1, 1995·Current Biology : CB·J García-AñoverosMartin Chalfie
Sep 10, 2011·Neuron·Aislyn M NelsonEllen A Lumpkin
Oct 1, 1995·Kidney International·C M CanessaB C Rossier
Sep 3, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·I Mano, Monica Driscoll
Apr 3, 1999·The Journal of Biological Chemistry·S CoscoyM Lazdunski
Oct 21, 2016·American Journal of Physiology. Cell Physiology·Cristina MatthewmanLaura Bianchi
Sep 24, 2004·Physiological Reviews·Popi Syntichaki, Nektarios Tavernarakis
Jul 13, 2018·Channels·Alexis S Hill, Yehuda Ben-Shahar
Sep 26, 2018·ELife·Sigrid NorengIsabelle Baconguis
Feb 14, 1991·Nature·J Hodgkin
Feb 11, 1993·Nature·Martin ChalfieM Huang
Feb 3, 1994·Nature·T J Jentsch
May 26, 2005·American Journal of Physiology. Renal Physiology·Nikki L Jernigan, H A Drummond
Aug 2, 2003·Nature Reviews. Neuroscience·Popi Syntichaki, Nektarios Tavernarakis
Jun 22, 2018·Open Biology·Athanasios MetaxakisNektarios Tavernarakis
Apr 26, 2018·American Journal of Physiology. Cell Physiology·Cristina MatthewmanLaura Bianchi
Nov 17, 1995·The Journal of Biological Chemistry·R WaldmannM Lazdunski
Aug 26, 1998·The Journal of Biological Chemistry·C ChengM J Welsh
Oct 27, 1997·The Journal of Biological Chemistry·C M AdamsM J Welsh
Apr 5, 1996·The Journal of Biological Chemistry·M P PriceM J Welsh
Jul 1, 1996·Molecular Membrane Biology·T Le, M H Saier
Oct 12, 2018·American Journal of Physiology. Cell Physiology·Scott M O'Grady
Aug 22, 1997·The Journal of Biological Chemistry·R WaldmannM Lazdunski
Oct 12, 1999·The American Journal of Physiology·W P SchillingW G Sinkins
Jun 11, 2002·American Journal of Physiology. Cell Physiology·L M BrockwayK T Keyser
Jul 22, 1999·Annals of the New York Academy of Sciences·R WaldmannM Lazdunski
May 14, 2016·G3 : Genes - Genomes - Genetics·Yushu ChenMartin Chalfie
May 18, 2016·The Journal of Biological Chemistry·Shujie ShiThomas R Kleyman
Jan 19, 2006·Biochemistry. Biokhimii︠a︡·S Ya ProskuryakovA I Kolesnikova
Aug 5, 2016·The Journal of Biological Chemistry·Alexandr V IlyaskinSilke Haerteis
Feb 5, 2020·EMBO Reports·Natsune TakagakiAtsushi Kuhara
Mar 4, 2020·Proceedings of the National Academy of Sciences of the United States of America·Ching-Han LeeYen-Ping Hsueh
Nov 18, 2000·Journal of Neuropathology and Experimental Neurology·M B Feany
Jul 19, 2001·Annals of the New York Academy of Sciences·H A DrummondF M Abboud
Jan 15, 2019·PLoS Genetics·Mauricio CaneoAndrea Calixto
Mar 26, 2020·PLoS Biology·Arles UrrutiaAndrea Calixto
May 9, 1998·The Journal of Biological Chemistry·S CoscoyP Barbry
Feb 1, 1991·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·J B Martin

Related Concepts

Caenorhabditis
Cistron
Genetic Conditions, Dominant
Cell Surface Proteins
Nerve Degeneration
Suppressor Mutation
Gene Expression

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.