The identification of additional zebrafish DICP genes reveals haplotype variation and linkage to MHC class I genes

Immunogenetics
Ivan Rodriguez-NunezJeffrey A Yoder

Abstract

Bony fish encode multiple multi-gene families of membrane receptors that are comprised of immunoglobulin (Ig) domains and are predicted to function in innate immunity. One of these families, the diverse immunoglobulin (Ig) domain-containing protein (DICP) genes, maps to three chromosomal loci in zebrafish. Most DICPs possess one or two Ig ectodomains and include membrane-bound and secreted forms. Membrane-bound DICPs include putative inhibitory and activating receptors. Recombinant DICP Ig domains bind lipids with varying specificity, a characteristic shared with mammalian CD300 and TREM family members. Numerous DICP transcripts amplified from different lines of zebrafish did not match the zebrafish reference genome sequence suggesting polymorphic and haplotypic variation. The expression of DICPs in three different lines of zebrafish has been characterized employing PCR-based strategies. Certain DICPs exhibit restricted expression in adult tissues whereas others are expressed ubiquitously. Transcripts of a subset of DICPs can be detected during embryonic development suggesting roles in embryonic immunity or other developmental processes. Transcripts representing 11 previously uncharacterized DICP sequences were identified. The ...Continue Reading

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Citations

Mar 22, 2016·Fish & Shellfish Immunology·Dustin J Wcisel, Jeffrey A Yoder
May 26, 2017·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Dustin J WciselJeffrey A Yoder

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