The identification of the allylic nitrite and nitro derivatives of methyl linoleate and methyl linolenate by negative chemical ionization mass spectroscopy

Lipids
A A Gallon, W A Pryor

Abstract

The autoxidation of polyunsaturated fatty acids is initiated both in vivo and in vitro by nitrogen dioxide. The mechanism of the initiation process is believed to involve both addition reactions and hydrogen atom abstraction reactions, with hydrogen abstraction predominating at low levels of nitrogen dioxide. Therefore low levels of nitrogen dioxide should react with polyunsaturated fatty acids to give allylic derivatives; in an anaerobic system these derivations should be allylic nitro and nitrite compounds. Using negative methane chemical ionization mass spectrometry and other analytical techniques, we have identified these allylic nitrite and nitro compounds from the reactions of low levels of nitrogen dioxide with methyl linoleate and methyl linolenate in the absence of oxygen.

References

Jun 1, 1978·Environmental Research·T L Guidotti
Apr 1, 1989·Toxicology and Applied Pharmacology·E M Postlethwait, A Bidani
Jan 1, 1988·Journal of Toxicology and Environmental Health·A Richters
Mar 1, 1972·Archives of Environmental Health·R J StephensM J Evans
Oct 1, 1983·Environmental Health Perspectives·A Richters, K Kuraitis
Mar 1, 1983·Archives of Environmental Health·A Richters, V Richters
Jan 1, 1981·Archives of Environmental Health·A Richters, K Kuraitis

❮ Previous
Next ❯

Citations

May 20, 1994·Toxicology·E M Postlethwait, A Bidani
Jan 1, 1995·Toxicology Letters·G A AnsariM F Khan
Sep 1, 1995·Free Radical Biology & Medicine·R V CooneyL J Mordan
Feb 28, 2003·Ageing Research Reviews·Michael Balazy, Santosh Nigam
Nov 19, 2008·The Journal of Biological Chemistry·Volker RudolphBruce A Freeman
Oct 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·R J SinghB Kalyanaraman
Nov 22, 2002·Proceedings of the National Academy of Sciences of the United States of America·Dong Gun LimBruce A Freeman
Jul 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Paul R S BakerBruce A Freeman
Jul 9, 2008·Pharmacology & Therapeutics·Michael Balazy, Sylvain Chemtob
May 7, 2008·Free Radical Biology & Medicine·Kavita JainMichael Balazy
Nov 30, 2006·Redox Report : Communications in Free Radical Research·Tiffany A Reiter
Feb 10, 2009·Free Radical Biology & Medicine·Paul R S BakerBruce A Freeman
Aug 30, 2011·Nitric Oxide : Biology and Chemistry·Chang-Jiang GuoAndrew J Gow
Jul 3, 2003·Journal of Lipid Research·Emersom S LimaDulcineia S P Abdalla
Sep 7, 2002·Circulation Research·Jane E Freedman
Jul 10, 1999·The Journal of Biological Chemistry·V B O'DonnellB A Freeman
Jul 18, 2002·Chemical Research in Toxicology·Adrian C NicolescuGregory R J Thatcher
Feb 18, 2004·Chemical Research in Toxicology·Adrian C NicolescuGregory R J Thatcher
Nov 14, 2021·Planta·Luciano Di FinoAna M Laxalt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.