The Identity of "Chromium Malate"

Biological Trace Element Research
Megan SmartJohn B Vincent

Abstract

Recently, several studies on the effects of a compound named "chromium malate," with the proposed formula "Cr2malate3·xH2O" where x = 3.5 or 5, on the health of healthy and diabetic rats have appeared. However, the compound is poorly characterized, and knowing the identity of this material could be important in the interpretation of the previous and of future studies on the effects of this compound in animals. Consequently, the synthesis, characterization, and identity of this material were explored. A combination of spectroscopic, magnetic, and elemental analyses and mass spectral studies reveal that the compound is probably a polymer, not a discrete molecule, and does not have the composition previously reported. The repeating unit of the polymer possesses an antiferromagnetically coupled trinuclear Cr(III) core. The current study suggests that previous reports on chromium malate and its effects in animals must be viewed with caution.

References

Jan 23, 2009·Biological Trace Element Research·Nicholas R RhodesJohn B Vincent
Nov 19, 2010·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Kristin R Di BonaJohn B Vincent
Dec 17, 2010·Biological Trace Element Research·Xiang-Yang WuLiu-Qing Yang
Jul 22, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·John B Vincent
Sep 16, 2014·Inorganic Chemistry·T H Nguyen PhamPeter A Lay

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Citations

Oct 3, 2019·Current Opinion in Clinical Nutrition and Metabolic Care·John B Vincent

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Methods Mentioned

BETA
nuclear magnetic resonance
NMR
electron paramagnetic resonance

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