The IFN-γ-p38, ERK kinase axis exacerbates neutrophilic chronic rhinosinusitis by inducing the epithelial-to-mesenchymal transition

Mucosal Immunology
Mingyu LeeHyun-Woo Shin

Abstract

Chronic rhinosinusitis (CRS) is a heterogeneous and multifactorial inflammatory disease characterized by involvement of diverse types of inflammatory cells. Asian CRS patients frequently show infiltration of neutrophils and an elevated level of interferon (IFN)-γ; by contrast, western patients exhibit eosinophil infiltration and enhanced levels of Th2-related cytokines. Neutrophilia in tissues decreases sensitivity to corticosteroids, but the mechanisms underlying the progression of neutrophilic CRS are unclear. In this study, we investigated the role of IFN-γ in CRS patients with marked neutrophil infiltration. We report that the IFN-γ level is upregulated in the tissues of these patients, particularly those with non-eosinophilic nasal polyps. The level of IFN-γ was significantly correlated with markers of the epithelial-to-mesenchymal transition (EMT). We further demonstrated that IFN-γ induced the EMT via the p38 and extracellular signal-regulated kinase (ERK) pathways in a manner distinct from the hypoxia-inducible factor (HIF)-1α, SMAD, and NF-κB signaling pathways. In a murine nasal polyp (NP) model, blocking the p38 and ERK signaling pathways prevented NP formation and chemotactic cytokine secretion by neutrophils but no...Continue Reading

References

Jun 1, 1997·The Journal of Allergy and Clinical Immunology·C BachertC Rudack
Nov 8, 2001·American Journal of Physiology. Cell Physiology·M AhdiehA Youakim
Apr 4, 2002·Trends in Immunology·Chilakamarti V RamanaGeorge R Stark
May 6, 2004·The Laryngoscope·Rhoda Wynn, Gady Har-El
May 3, 2005·Nature Reviews. Immunology·Leonidas C Platanias
Jun 1, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Matthias BruewerAsma Nusrat
Apr 6, 2006·The Laryngoscope·Abraham Jacob, Richard A Chole
Apr 15, 2006·American Journal of Respiratory and Critical Care Medicine·Mark HewKian Fan Chung
Jun 19, 2007·The Laryngoscope·Te-Huei YehShiann-Yann Lee
Feb 1, 2008·The Journal of Allergy and Clinical Immunology·Catherine Butkus SmallAngela Damiano
Apr 22, 2008·The Journal of Allergy and Clinical Immunology·Nicholas Van BruaenePhilippe Gevaert
Sep 23, 2008·The Journal of Allergy and Clinical Immunology·Nan ZhangClaus Bachert
Oct 22, 2008·Cytokine & Growth Factor Reviews·Daniel J GoughChristopher J Clarke
May 2, 2009·American Journal of Respiratory and Critical Care Medicine·Tillie-Louise HackettDarryl A Knight
Jun 3, 2009·The Journal of Clinical Investigation·Hervé AcloqueM Angela Nieto
Jun 9, 2009·The Journal of Allergy and Clinical Immunology·Nicholas Van BruaeneClaus Bachert
Jun 23, 2009·The Journal of Allergy and Clinical Immunology·Ping-Ping CaoZheng Liu
Jun 1, 2011·Laboratory Investigation; a Journal of Technical Methods and Pathology·Jee Young SungByung-Kiu Park
Jul 7, 2011·Proceedings of the National Academy of Sciences of the United States of America·Nam-Gyun KimBarry M Gumbiner
Sep 6, 2011·The Journal of Allergy and Clinical Immunology·Daniel L Hamilos
Sep 8, 2011·The Laryngoscope·Spencer C PayneJohn W Steinke
Nov 19, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N Van BruaeneC Bachert
Nov 19, 2011·American Journal of Respiratory and Critical Care Medicine·Nizar N JarjourUNKNOWN NHLBI Severe Asthma Research Program (SARP)
Feb 11, 2012·American Journal of Respiratory and Critical Care Medicine·Hyun-Woo ShinJong-Wan Park
Mar 31, 2012·The Journal of Allergy and Clinical Immunology·Weiping WenUNKNOWN Nasal Health Group, China (NHGC)
Jul 31, 2012·The Journal of Allergy and Clinical Immunology·Michael B SoykaCezmi A Akdis
Oct 23, 2013·Journal of Visualized Experiments : JoVE·Loretta MüllerIlona Jaspers
Oct 15, 2014·The Journal of Allergy and Clinical Immunology·Mahboobeh MahdaviniaRobert P Schleimer
Dec 18, 2014·World Journal of Clinical Cases·En-Tong WangLi-Juan Guo
Jun 30, 2015·The Journal of Clinical Investigation·Mahesh RaundhalAnuradha Ray
Sep 8, 2015·The Journal of Allergy and Clinical Immunology·Mingyu LeeHyun-Woo Shin
Nov 26, 2015·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Shintaro BabaTatsuya Yamasoba
Mar 8, 2016·The Journal of Allergy and Clinical Immunology·Peter TomassenClaus Bachert
May 12, 2016·Brazilian Journal of Otorhinolaryngology·Changzhi SunRenzhong Luo
Aug 22, 2016·The Journal of Allergy and Clinical Immunology·Xiangdong WangClaus Bachert
Dec 14, 2016·Annual Review of Pathology·Robert P Schleimer

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Citations

Aug 10, 2019·Clinical and Experimental Otorhinolaryngology·Hai WangZheng Liu
Sep 24, 2020·International Journal of Molecular Sciences·Emanuela ChiarellaMaria Mesuraca
Feb 6, 2020·Allergy, Asthma & Immunology Research·Roza KhalmuratovaHyun Woo Shin
Dec 8, 2020·Current Opinion in Allergy and Clinical Immunology·Gwanghui RyuHyun-Woo Shin
Mar 16, 2021·Frontiers in Immunology·Juliana de Melo Batista Dos SantosAndré Luis Lacerda Bachi
Mar 6, 2021·The Journal of Allergy and Clinical Immunology·Jin Youp KimDae Woo Kim
May 7, 2021·The Journal of Allergy and Clinical Immunology·Mingyu LeeHyun-Woo Shin
Jul 27, 2021·Frontiers in Allergy·Erik D AndersonIan A Myles
Aug 28, 2021·Frontiers in Immunology·Mikel Etxebeste-MitxeltorenaBeatriz Martín-Antonio

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
transfection
Assay
PCR
lavage

Software Mentioned

SigmaPlot
Prism
ImageJ
GraphPad
SPSS

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