The IFN-gamma-dependent suppressor of cytokine signaling 1 promoter activity is positively regulated by IFN regulatory factor-1 and Sp1 but repressed by growth factor independence-1b and Krüppel-like factor-4, and it is dysregulated in psoriatic keratinocytes

The Journal of Immunology : Official Journal of the American Association of Immunologists
Stefania MadonnaCristina Albanesi

Abstract

Epidermal keratinocytes can counteract the detrimental effects of IFN-gamma by inducing the expression of suppressor of cytokine signaling (SOCS)1, which plays an important anti-inflammatory and self-protective role. To date, limited information exists on its expression and regulation in human diseased keratinocytes. In this study, we compared the expression levels of SOCS1 in keratinocytes isolated from skin affected by psoriasis with cells obtained from healthy donors, unveiling that keratinocytes are more prone than healthy cells to upregulate SOCS1 mRNA expression in response to IFN-gamma. We explored the regulatory mechanisms involved in socs1 gene transcription, and found that Sp1 and IFN regulatory factor-1 transcription factors are, respectively, responsible for the basal and IFN-gamma-induced activity of human socs1 promoter. In parallel, we demonstrated that socs1 promoter is negatively regulated by two transcriptional repressors, namely, growth factor independence-1b and Krüppel-like factor 4, which tightly control SOCS1 transcription on IFN-gamma stimulation. Interestingly, although the expression of Sp1 and IFN regulatory factor-1 activators of socs1 promoter is unaltered, growth factor independence-1b and Krüppel-...Continue Reading

References

Apr 1, 1990·The British Journal of Dermatology·J N BarkerD M MacDonald
Nov 1, 1986·The Journal of Investigative Dermatology·N E WiknerW L Weston
Dec 22, 1995·The Journal of Biological Chemistry·D C LookM J Holtzman
May 23, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·H SaitoT Kishimoto
Jul 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·C AlbanesiG Girolomoni
Jul 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·D MetcalfW S Alexander
Jan 9, 2001·The Journal of Investigative Dermatology. Symposium Proceedings·B J Nickoloff
Jun 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Monica FedericiCristina Albanesi
Mar 7, 2003·Genome Biology·Joanna KaczynskiRaul Urrutia
Apr 3, 2003·Immunological Reviews·Subburaj Ilangumaran, Robert Rottapel
May 7, 2003·The Journal of Biological Chemistry·Rong-Lin XieAndre J van Wijnen
Nov 25, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniel HebenstreitJutta Horejs-Hoeck
Jun 17, 2004·The Journal of Biological Chemistry·Julia TravagliJosiane Pierre
Sep 24, 2004·Current Opinion in Genetics & Development·Xing Dai, Julia A Segre
May 3, 2005·Nature Reviews. Immunology·Leonidas C Platanias
Aug 17, 2005·Current Drug Targets. Inflammation and Allergy·Cristina AlbanesiGiampiero Girolomoni
Oct 13, 2005·European Journal of Immunology·Xiaolan ZhangBrad H Rovin
Mar 18, 2006·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Claudia ScarponiCristina Albanesi
Apr 18, 2006·The Journal of Biological Chemistry·Huijun WeiJihe Zhao
Apr 3, 2007·Nature Protocols·Pradnya GangatirkarPritinder Kaur
Apr 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lilian W WaibociHoward M Johnson
Oct 2, 2007·The International Journal of Biochemistry & Cell Biology·Richard PearsonShisan Bao
Nov 21, 2007·Clinics in Dermatology·Cristina AlbanesiGiampiero Girolomoni
Nov 21, 2007·Clinics in Dermatology·Erwin Tschachler
Dec 21, 2007·Clinical Reviews in Allergy & Immunology·Brian J NickoloffFrank O Nestle
Jun 17, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Stefania MadonnaCristina Albanesi
Aug 19, 2008·Seminars in Cell & Developmental Biology·Ben A CrokerSandra E Nicholson
Aug 30, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Andrea BaetzAlexander H Dalpke
Jun 2, 2009·Molecular Immunology·Martine LetourneurJosiane Pierre
Jun 12, 2009·Molecular Immunology·Christian KoelscheAlexander H Dalpke
Nov 6, 2009·The Journal of Investigative Dermatology·Francesca MasciaSaveria Pastore

❮ Previous
Next ❯

Citations

Jun 29, 2012·Cell Death & Disease·S MadonnaC Albanesi
Jan 27, 2011·Drug Design, Development and Therapy·Ignacio Garcia-ValladaresLuis R Espinoza
Nov 8, 2011·Annual Review of Pathology·Gayathri K PereraFrank O Nestle
Feb 9, 2011·Expert Opinion on Drug Metabolism & Toxicology·Neill James Liptrott, Andrew Owen
Jul 23, 2014·Asian-Australasian Journal of Animal Sciences·Li-Fang SiXiang-Chao Cheng
Dec 15, 2011·The Biochemical Journal·Nunzianna DotiDaniela Marasco
Aug 10, 2016·BMC Systems Biology·Yan HuangAnd Lin-Sen Zan
Mar 25, 2017·Expert Opinion on Drug Metabolism & Toxicology·Sharon M SeifertPeter L Anderson
May 29, 2018·Microbiology and Immunology·Tengda LiAnmei Deng
Mar 7, 2014·European Journal of Immunology·Yan LiangDong-Qing Ye
Dec 5, 2014·Annals of Dermatology·Kwang Joong KimKwang Ho Kim
Mar 31, 2016·Clinical Reviews in Allergy & Immunology·Yaxiong DengQianjin Lu
Apr 18, 2013·European Journal of Immunology·Stefania MadonnaCristina Albanesi
Dec 29, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pragya ChandrakarSusanta Kar
Dec 6, 2019·The Journal of Clinical Investigation·Takashi K SatohLars E French
Nov 19, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Julia StrebovskyAlexander H Dalpke
Oct 17, 2015·The British Journal of Dermatology·B GubánZ Bata-Csörgő
Jun 23, 2021·Nature Reviews. Immunology·Angela M GocherDario A A Vignali

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.