The IgA nephropathy treatment dilemma

Kidney International
Gerald Appel, M Waldman

Abstract

Although IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide, our understanding of the pathogenesis of this complex disease remains limited. IgA nephropathy may appear with a variety of clinical presentations, a number of different clinical and histopathologic risk factors for progressive renal disease, and a very variable course over time. Thus, it is not surprising that a single therapeutic treatment plan has not been established. Many of the studies dealing with IgAN are retrospective, lack statistical significance, or have confounding designs, which hinder their general acceptance. Nevertheless, a number of well-designed studies have been performed. This paper reviews currently available therapeutic options for IgAN. It attempts to address several important questions: Why do we treat patients with IgAN? How do we decide which patients should be treated? What are the general treatment guidelines for all IgAN patients? What is the role of specific therapy such as fish oils, tonsillectomy, and immunosuppression in the treatment of patient with IgAN? It also addresses several on-going trials and goals for future therapeutic studies for IgAN patients.

References

May 5, 1984·Lancet·T HamazakiH Shishido
Nov 3, 1994·The New England Journal of Medicine·J V DonadioK E Holley
Apr 23, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D RussoR Minutolo
Jan 3, 2001·Kidney International·L F FriedB L Kasiske
Mar 29, 2001·Journal of the American Society of Nephrology : JASN·James V DonadioJoseph P Grande
Sep 29, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·L P BartosikD C Cattran
Sep 29, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·O HottaY Taguma
Dec 26, 2001·Journal of the American Society of Nephrology : JASN·Francis W Ballardie, Ian S D Roberts
Jul 10, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·James V DonadioDiana M Rademcher
Mar 4, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Stefano BianchiVito M Campese
Mar 5, 2003·Nephron. Clinical Practice·Dimitrios S GoumenosColin B Brown
Apr 5, 2003·Kidney International·Yuansheng XieFumitake Gejyo
May 2, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ritsuko KatafuchiSatoru Fujimi
May 23, 2003·Journal of the American Society of Nephrology : JASN·Manuel PragaEduardo Hernández
Dec 25, 2003·Journal of the American Society of Nephrology : JASN·Claudio PozziFrancesco Locatelli
May 25, 2004·Seminars in Nephrology·James V Donadio, Joseph P Grande
May 25, 2004·Seminars in Nephrology·James A Tumlin, R A Hennigar
Sep 24, 2004·The New England Journal of Medicine·Alan S GoChi-yuan Hsu
Dec 2, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Juhani MyllymäkiJukka Mustonen
Jul 15, 2005·Kidney International·Sydney TangKar Neng Lai
Jul 21, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gershon FrischGerald Appel
Aug 18, 2005·Kidney International·Yoshiharu NishitaniEric G Neilson
Nov 25, 2005·The New England Journal of Medicine·Ellen M GinzlerGerald B Appel

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Citations

Nov 24, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Luis Aldámiz-EchevarríaJuan Rodríguez-Soriano
Dec 3, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Yuko ShimaNorishige Yoshikawa
Sep 4, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Yuko ShimaNorishige Yoshikawa
Dec 6, 2012·Chinese Journal of Integrative Medicine·Jian-Jun LiRi-Bao Wei
Jan 29, 2009·Nature Clinical Practice. Nephrology·Alice S Appel, Gerald B Appel
Jan 22, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jing XiaoKar Neng Lai
Mar 5, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Antonio PiccoliBarbara Rossi
Jul 6, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Yuko ShimaNorishige Yoshikawa
Aug 9, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Rune BjørneklettBjarne M Iversen
Apr 12, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Isseki MaedaMasahito Imanishi
Mar 12, 2008·Current Opinion in Pediatrics·Raymond Quigley
Jul 17, 2012·Journal of the American Society of Nephrology : JASN·Keiko OkazakiYasuhiko Tomino
Sep 8, 2012·Journal of the American Society of Nephrology : JASN·Eduardo GutiérrezUNKNOWN Grupo de Estudio de Enfermedades Glomerulares de la Sociedad Española de Nefrología (GLOSEN)
Feb 16, 2012·International Journal of Nephrology and Renovascular Disease·Ipek Kaplan BulutNida Dincel
May 30, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Hiroyuki KomatsuKazuo Kitamura
Apr 16, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Koichi KameiUNKNOWN Japanese Pediatric IgA Nephropathy Treatment Study Group
Nov 11, 2010·Journal of Athletic Training·James E LeoneRobert M Colandreo
Mar 7, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tetsuya KawamuraUNKNOWN Special IgA Nephropathy Study Group
Sep 14, 2007·Seminars in Immunopathology·Jonathan BarrattJohn Feehally
Sep 10, 2010·Clinical and Experimental Nephrology·Yoshitaka IwazuEiji Kusano
Nov 11, 2011·Clinical and Experimental Nephrology·Maki ShinzawaHiromi Rakugi
Jul 9, 2013·Metabolomics : Official Journal of the Metabolomic Society·Angela M ZivkovicBruce D Hammock
Nov 28, 2013·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Lei-Ting LiBing Li
Feb 10, 2012·Kidney International·Joanna K BoydJonathan Barratt
Jun 19, 2012·The Medical Clinics of North America·Ajay Kher, Vijay Kher
Jun 3, 2008·Kidney International·A Rifai, L D Dworkin
Oct 26, 2010·Transplantation Proceedings·P HidalgoD Hernández
Apr 20, 2010·Néphrologie & thérapeutique·Evangéline Pillebout, Dominique Nochy
Feb 9, 2010·Biochemical and Biophysical Research Communications·Kenichiro IioHiromi Rakugi
Jun 7, 2007·Mayo Clinic Proceedings·Bettina M KnollMarie C Hogan
Jun 30, 2007·Journal of the American Academy of Dermatology·Ken NatsugaHiroshi Shimizu
May 9, 2007·Current Problems in Pediatric and Adolescent Health Care·Abiodun A OmolojaElizabeth Jackson
May 7, 2015·Nephrology·Ilaria SerrielloKonstantinos Giannakakis
Mar 2, 2010·Prostaglandins, Leukotrienes, and Essential Fatty Acids·James J Pestka
Dec 10, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Koichi KameiUNKNOWN Japanese Pediatric IgA Nephropathy Treatment Group
Jun 22, 2016·Néphrologie & thérapeutique·Evangéline Pillebout, Jérôme Vérine
Oct 11, 2016·International Urology and Nephrology·Jiayu DuanZhangzuo Liu

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