The IGF system and cytokine interactions and relationships with longitudinal growth in prepubertal patients with cystic fibrosis

Clinical Endocrinology
Maria E StreetSergio Bernasconi

Abstract

Growth delay is a feature of patients with cystic fibrosis (CF). CF is a condition characterized by chronic inflammation that has been shown to modify the IGF system, which is essential for normal growth, and is related to pulmonary function in CF patients. We aimed to verify whether circulating levels of tumour necrosis factor (TNF)-alpha, interleukin (IL)-6, insulin and the IGF system were related and/or had relationships with linear growth in children with CF. Seventeen prepubertal CF patients (nine males and eight females) in a stable clinical condition were enrolled. Auxological parameters, pulmonary function and the Shwachman-Kulczycki (S-K) score were assessed, and serum samples were drawn at baseline and after 12 months. TNF-alpha, IL-6, IGF-I, IGF-II, IGFBP-1, IGFBP-2, IGFBP-3 and insulin were assayed using specific commercial kits. At baseline, TNF-alpha serum concentration was related to serum IGF-I concentration (R = 0.53), IGF-II bioactivity (IGF-II/IGFBP-3 molar ratio, R = +0.52) and insulin concentration (R = +0.63). Changes in serum IL-6 and IGFBP-2 concentrations during the 12-month observation were positively correlated (R = +0.63). Changes in height standard deviation score (Ht SDS) were correlated with IGF-I...Continue Reading

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Citations

Nov 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Mark P RoganDavid A Stoltz
Dec 17, 2014·Arthritis & Rheumatology·Fabrizio De BenedettiUNKNOWN Paediatric Rheumatology International Trials Organisation and the Pediatric Rheumatology Collaborative Study Group
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Jul 19, 2018·BioMed Research International·Zheng WangXiaoju Zhang

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