The IGF1 pathway genes and their association with age of puberty in cattle

Animal Genetics
Marina R S FortesRachel J Hawken

Abstract

Insulin-like growth factor I (somatomedin C) (IGF1) influences gonadotrophin-releasing hormone (GnRH) neurons during puberty, and GnRH release guides pubertal development. Therefore, genes of the IGF1 pathway are biological candidates for the identification of single-nucleotide polymorphisms (SNPs) affecting age of puberty. In a genome-wide association study, genotyped heifers were Tropical Composite (TCOMP, n = 866) or Brahman (BRAH, n = 843), with observation of age at first corpus luteum defining puberty. We examined SNPs in or near genes of the IGF1 pathway and report seven genes associated with age at puberty in cattle: IGF1R, IGFBP2, IGFBP4, PERK (HUGO symbol EIF2AK3), PIK3R1, GSK3B and IRS1. SNPs in the IGF1 receptor (IGF1R) showed the most promising associations: two SNPs were associated with puberty in TCOMP (P < 0.05) and one in BRAH (P = 0.00009). This last SNP explained 2% of the genetic variation (R(2) = 2.04%) for age of puberty in BRAH. Hence, IGF1R was examined further. Additional SNPs were genotyped, and haplotypes were analysed. To test more SNPs in this gene, four new SNPs from dbSNP were selected and genotyped. Single SNP and haploytpe analysis revealed associations with age of puberty in both breeds. There ...Continue Reading

References

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Citations

Mar 11, 2015·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·A A AliP C Thomson
May 31, 2016·Theriogenology·Marina R S FortesMilton G Thomas
Nov 3, 2016·Frontiers in Veterinary Science·Mayara Morena Del Cambre Amaral WellerStephen Stewart Moore
Oct 11, 2017·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·R R MotaS Moore
Oct 24, 2017·Animal : an International Journal of Animal Bioscience·M V C FerrazG P Nogueira
Sep 4, 2014·Animal Genetics·A L SomavillaL C A Regitano
May 21, 2020·Veterinary Medicine and Science·Li Yieng LauMarina R S Fortes
Jun 22, 2019·BMC Genomics·Xiaolong YuanZhe Zhang
Sep 6, 2020·Genetics, Selection, Evolution : GSE·Seyed Mohammad GhoreishifarArash Javanmard
Jun 10, 2021·Tropical Animal Health and Production·Norberto Ismael Angulo-ValenzuelaPablo Luna-Nevárez

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