PMID: 25742787Mar 7, 2015Paper

The IgH 3' regulatory region governs μ chain transcription in mature B lymphocytes and the B cell fate

Oncotarget
Alexis SaintamandYves Denizot

Abstract

We report that the IgH 3' regulatory region (3'RR) has no role on μ chain transcription and pre-BCR expression in B cell progenitors. In contrast, analysis of heterozygous IgH aΔ3'RR/bwt mice indicated that the 3'RR controls μ chain transcripts in mature splenocytes and impacts membrane IgM density without obvious effect on BCR signals (colocalisation with lipid rafts and phosphorylation of Erk and Akt after BCR crosslinking). Deletion of the 3'RR modulates the B cell fate to less marginal zone B cells. In conclusion, the 3'RR is dispensable for pre-BCR expression and necessary for optimal commitments toward the marginal zone B cell fate. These results reinforce the concept of a dual regulation of the IgH locus transcription and accessibility by 5' elements at immature B cell stages, and by the 3'RR as early as the resting mature B cell stage and then along further activation and differentiation.

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Citations

May 1, 2015·Cell Cycle·Alexis SaintamandYves Denizot
May 1, 2019·Médecine sciences : M/S·Hussein IssaouiYves Denizot
Jun 19, 2020·International Journal of Molecular Sciences·Eleonora VecchioIleana Quinto
Feb 3, 2016·Proceedings of the National Academy of Sciences of the United States of America·Armand GarotEric Pinaud
Oct 13, 2016·Oncotarget·Nour GhazzauiYves Denizot
Dec 5, 2017·Médecine sciences : M/S·Alexis SaintamandYves Denizot
Mar 30, 2017·Scientific Reports·A SaintamandY Denizot
Oct 12, 2018·Cellular & Molecular Immunology·Nour GhazzauiYves Denizot

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