The ihog cell-surface proteins bind Hedgehog and mediate pathway activation

Cell
Shenqin YaoPhilip A Beachy

Abstract

The ihog gene (interference hedgehog), identified by RNA interference in Drosophila cultured cells, encodes a type 1 membrane protein shown here to bind and to mediate response to the active Hedgehog (Hh) protein signal. ihog mutations produce defects characteristic of Hh signaling loss in embryos and imaginal discs, and epistasis analysis places ihog action at or upstream of the negatively acting receptor component, Patched (Ptc). The first of two extracellular fibronectin type III (FNIII) domains of the Ihog protein mediates a specific interaction with Hh protein in vitro, but the second FNIII domain is additionally required for in vivo signaling activity and for Ihog-enhanced binding of Hh protein to cells coexpressing Ptc. Other members of the Ihog family, including Drosophila Boi and mammalian CDO and BOC, also interact with Hh ligands via a specific FNIII domain, thus identifying an evolutionarily conserved family of membrane proteins that function in Hh signal response.

References

Oct 30, 1980·Nature·C Nüsslein-Volhard, E Wieschaus
Oct 24, 1998·The Journal of Cell Biology·J S KangR S Krauss
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·N FuseP A Beachy
Jan 2, 2003·Current Topics in Developmental Biology·Andrew P McMahonClifford J Tabin
Mar 7, 2003·Current Biology : CB·Francesca Cole, Robert S Krauss
Mar 14, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jong-Sun KangRobert S Krauss
Jun 11, 2004·Annual Review of Biochemistry·Randall K Mann, Philip A Beachy
Jun 19, 2004·Science·Lawrence Lum, Philip A Beachy
Nov 3, 2004·The Journal of Cell Biology·Jong-Sun KangRobert S Krauss
Nov 19, 2004·Nature·Philip A BeachyDavid M Berman
Dec 16, 2004·Proceedings of the National Academy of Sciences of the United States of America·Chi ZhangPhilip A Beachy
Mar 19, 2005·The Journal of Comparative Neurology·Robin M ConnorBrian Key

❮ Previous
Next ❯

Citations

Jul 9, 2013·Physics of Life Reviews·M VerbeniJ Soler
Jul 2, 2008·Nature Cell Biology·Dong Yan, Xinhua Lin
Jan 20, 2009·Nature Chemical Biology·Benjamin Z StantonStuart L Schreiber
Mar 17, 2009·Nature Neuroscience·Jennifer A ChanRosalind A Segal
Dec 2, 2006·Nature Reviews. Drug Discovery·Lee L Rubin, Frederic J de Sauvage
Oct 19, 2006·Nature Reviews. Genetics·Philip W Ingham, Marysia Placzek
Jun 30, 2009·Nature Structural & Molecular Biology·Ivan BosanacRobert A Lazarus
Feb 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Min Lu, Robert S Krauss
Mar 17, 2010·Proceedings of the National Academy of Sciences of the United States of America·Elizabeth H WilliamsPhilip A Beachy
Jun 22, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ainhoa CallejoIsabel Guerrero
Aug 11, 2011·Proceedings of the National Academy of Sciences of the United States of America·Min-Sung KimDaniel J Leahy
May 30, 2009·The Journal of Biological Chemistry·David C Martinelli, Chen-Ming Fan
Jan 13, 2010·Cold Spring Harbor Perspectives in Biology·Dong Yan, Xinhua Lin
May 17, 2007·Genes & Development·David C Martinelli, Chen-Ming Fan
Jan 6, 2010·Genes & Development·Xiaoyan ZhengPhilip A Beachy
Sep 17, 2010·Genes & Development·Philip A BeachyChristian Siebold
Mar 27, 2007·Cold Spring Harbor Symposia on Quantitative Biology·B Mathey-Prevot, N Perrimon
Oct 6, 2007·Science·Leni Jacob, Lawrence Lum
Oct 18, 2012·Science Signaling·David J RobbinsNatalia A Riobo
Feb 2, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Shohreh F FarzanDavid J Robbins
Nov 4, 2010·Neural Development·Darius CampFrédéric Charron
Jun 10, 2010·Development·Christopher W Wilson, Pao-Tien Chuang
Dec 25, 2010·Disease Models & Mechanisms·Wei ZhangRobert S Krauss
Jan 5, 2011·Chinese Journal of Cancer·Hailan LiuJingwu Xie
Nov 19, 2010·Regenerative Medicine·Linda Maria JäderstadEric Herlenius
Nov 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jason S McLellanDaniel J Leahy
Nov 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Andrew Beenken, Moosa Mohammadi
Oct 5, 2010·Annual Review of Pharmacology and Toxicology·Michael E Dodge, Lawrence Lum
Nov 26, 2010·The Journal of Cell Biology·Tiffiney R HartmanAlana M O'Reilly
Aug 6, 2008·The Journal of Cell Biology·Jong-Sun KangRobert S Krauss
May 22, 2013·The Journal of Cell Biology·Tiffiney R HartmanAlana M O'Reilly

❮ Previous
Next ❯

Related Concepts

Related Feeds

CZI Human Cell Atlas Seed Network

The aim of the Human Cell Atlas (HCA) is to build reference maps of all human cells in order to enhance our understanding of health and disease. The Seed Networks for the HCA project aims to bring together collaborators with different areas of expertise in order to facilitate the development of the HCA. Find the latest research from members of the HCA Seed Networks here.

Cell eTOC

Cell is a scientific journal publishing research across a broad range of disciplines within the life sciences field. Discover the latest research from Cell here.