The IL-2 defect in systemic lupus erythematosus disease has an expansive effect on host immunity.

Journal of Biomedicine & Biotechnology
Linda A Lieberman, George C Tsokos

Abstract

IL-2 production is decreased in systemic lupus erythematosus (SLE) patients and affects T cell function and other aspects of host immunity. Transcription factors regulating IL-2 production behave aberrantly in SLE T cells. In addition to IL-2 dysregulation, other IL-2 family members (IL-15 and IL-21) are abnormally expressed in SLE. Decreased IL-2 production in SLE patients leads to many immune defects such as decreased T(reg) production, decreased activation-induced cell death (AICD), and decreased cytotoxicity. IL-2 deficiency results in systemic dysregulation of host immune responses in patients suffering from SLE disease.

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Citations

Sep 1, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Sokratis A ApostolidisGeorge C Tsokos
Oct 27, 2011·Journal of Biomedicine & Biotechnology·Kim Ohl, Klaus Tenbrock
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Methods Mentioned

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