The IL-4, IL-13 and IL-31 pathways in atopic dermatitis.

Expert Review of Clinical Immunology
Celina DubinEmma Guttman-Yassky

Abstract

Introduction: Atopic dermatitis (AD) is the most common inflammatory skin disease. It has a complex pathophysiology, with a combination of immune dysregulation and intrinsic barrier defects driving cutaneous inflammation and allergic symptomatology. The IL-4, IL-13 and IL-31 inflammatory pathways have been identified as hallmark features in the pathogenesis of the disease, contributing uniquely and synergistically to immune and barrier abnormalities as well as the key symptoms, such as pruritis. Novel therapeutics that target these pathways have been under development to find treatments for AD.Areas covered: This review discusses the IL-4, IL-13 and IL-31 pathways in AD. We will also detail novel targeted therapeutics that have recently been or are currently in clinical trials for AD. A literature search was conducted by querying Scopus, Google Scholar, PubMed, and Clinicaltrials.gov up to January 2021 using combinations of the search terms 'IL-4' 'IL-13' 'IL-31' 'atopic dermatitis' 'immune pathway' 'biologics' 'novel therapeutics' 'JAK/STAT inhibitors.'Expert opinion: The complex pathophysiology of AD advocates for innovation. Novel minimally invasive sampling modalities such as tape stripping will allow for a broader characte...Continue Reading

References

Sep 1, 1992·The Journal of Allergy and Clinical Immunology·K JujoD Y Leung
Jan 1, 1994·Advances in Experimental Medicine and Biology·A KeeganW E Paul
Sep 1, 1994·The British Journal of Dermatology·L HorsmanheimoM Horsmanheimo
Jul 1, 1996·The Journal of Allergy and Clinical Immunology·Q HamidD Y Leung
Jan 1, 1995·Cancer Treatment and Research·R K Puri
Nov 5, 1998·Veterinary Immunology and Immunopathology·A GröneW Baumgärtner
Jun 8, 1999·Annual Review of Immunology·K NelmsW E Paul
Dec 10, 1999·Nature·D B Corry, F Kheradmand
May 16, 2002·International Journal of Dermatology·Gwendoline KiebertDavid Fivenson
Jun 29, 2002·Veterinary Immunology and Immunopathology·A Gröne
Nov 5, 2002·Journal of Dermatological Science·Yuichiro TsunemiKunihiko Tamaki
Nov 8, 2002·Biochimica Et Biophysica Acta·Thomas D MuellerAlbert Duschl
Apr 22, 2003·The Journal of Allergy and Clinical Immunology·Gurjit K Khurana Hershey
Sep 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ichiro NomuraDonald Y M Leung
Dec 4, 2003·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·T HummelshojA Svejgaard
Dec 4, 2003·Biochemical and Biophysical Research Communications·Mamoru YoshikawaHirohisa Saito
Dec 6, 2003·The Journal of Allergy and Clinical Immunology·Jonathan M Spergel, Amy S Paller
Dec 6, 2003·The Journal of Allergy and Clinical Immunology·Natalija NovakDonald Y M Leung
Mar 3, 2004·The Journal of Clinical Investigation·Donald Y M LeungQutayba A Hamid
Mar 5, 2004·The British Journal of Dermatology·M A Ben-GashirR J Hay
Mar 12, 2004·Archives of Dermatological Research·Takahiro TazawaMasami Uehara
Jun 9, 2004·Nature Immunology·Stacey R DillonJane A Gross
Jun 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susan C FishMarion T Kasaian
Feb 8, 2006·The Journal of Allergy and Clinical Immunology·Eniko SonkolyBernhard Homey
Jul 18, 2006·The Journal of Investigative Dermatology·Martin SteinhoffTamás Bíró
Oct 13, 2006·The Journal of Allergy and Clinical Immunology·Mark M NeisHeike M Hermanns
Feb 28, 2007·BMC Dermatology·Michelle A LowesJames G Krueger
Apr 4, 2008·The Journal of Investigative Dermatology·Michael D HowellDonald Y M Leung
Apr 15, 2008·The Journal of Investigative Dermatology·Peter M Elias, Martin Steinhoff
Aug 6, 2008·The Journal of Allergy and Clinical Immunology·Ulrike RaapThomas Werfel
Sep 9, 2008·World Journal of Gastroenterology : WJG·Akira AndohYoshihide Fujiyama
Oct 18, 2008·Cytokine & Growth Factor Reviews·Qing ZhangWenda Gao
Dec 2, 2008·Experimental Dermatology·Ehrhardt ProkschJens-Michael Jensen
Jun 6, 2009·The Journal of Investigative Dermatology·Michael J CorkSimon J Ward
Sep 2, 2009·The Journal of Allergy and Clinical Immunology·Michael D HowellDonald Y M Leung
Dec 17, 2009·The Journal of Allergy and Clinical Immunology·Joseph A OdhiamboUNKNOWN ISAAC Phase Three Study Group
Jan 30, 2010·The Journal of Allergy and Clinical Immunology·Mark Boguniewicz, Donald Y M Leung
Feb 12, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sarita SehraMark H Kaplan
Mar 2, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·François NiyonsabaKo Okumura
Jul 31, 2010·Immunology and Allergy Clinics of North America·Jonathan M Spergel
Aug 3, 2010·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Jonathan M Spergel

❮ Previous
Next ❯

Citations

Nov 2, 2021·Expert Review of Clinical Immunology·Giuseppe IngrasciGil Yosipovitch

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.