The IL23R Arg381Gln non-synonymous polymorphism confers susceptibility to ankylosing spondylitis

Annals of the Rheumatic Diseases
B RuedaJ Martin

Abstract

Recent results have shown that the IL23R gene, coding for a subunit of the interleukin-23 receptor, is strongly associated with autoimmunity. The aim of the current study was to investigate, for the first time, the possible involvement of the IL23R gene in genetic susceptibility to ankylosing spondylitis (AS). We carried out a case-control association study in which 365 patients with AS and 500 blood bank donors were included. Eight single nucleotide polymorphisms (SNPs) spanning the IL23R gene were selected as genetic markers for our association study and were genotyped using a Taqman 5' allelic discrimination assay. Interestingly, we observed association of two of eight IL23R genotyped SNPs. The strongest effect was conferred by the non-synonymous rs11209026 (Arg381Gln) SNP (odds ratio 0.46 95% confidence interval 0.2 to 0.7 p = 0.001). Similarly, the IL23R rs1343151 SNP showed association with AS genetic susceptibility (odds ratio 0.68 95% confidence interval 0.55 to 0.83 p = 0.0002). After a conditional case-control test we observed that the effect of these two genetic variants was independent of linkage disequilibrium. These results suggest that the IL23R gene seems to be involved in AS genetic predisposition.

Citations

Aug 23, 2008·Inflammatory Bowel Diseases·Dermot P B McGovernJerome I Rotter
Feb 15, 2011·Inflammatory Bowel Diseases·Alexandra I Thompson, Charlie W Lees
Sep 17, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Eniko SafranyBela Melegh
Nov 18, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Young Ho LeeGwan Gyu Song
Jan 24, 2009·Annals of Hematology·Tomoiku TakakuNeal S Young
Aug 13, 2011·Rheumatology International·Ali TaylanNurullah Akkoc
Oct 2, 2008·Clinical Rheumatology·Daniel WendlingEvelyne Racadot
Dec 17, 2010·Clinical Rheumatology·Yang MeiDongqing Ye
Feb 3, 2009·Nature Clinical Practice. Rheumatology·Kristine E NogralesAnne M Bowcock
Jun 19, 2010·Nature Reviews. Immunology·Daniel J Cua, Cristina M Tato
Apr 11, 2012·Nature Reviews. Rheumatology·John D Reveille
Oct 10, 2009·Rheumatology·Philippa HillyerFionula M Brennan
Apr 20, 2012·Rheumatology·Kirsty McHugh, Paul Bowness
Jun 6, 2008·Current Opinion in Rheumatology·Gerlinde Layh-Schmitt, Robert A Colbert
Jun 6, 2009·Current Opinion in Rheumatology·Matthew A Brown
Jan 20, 2010·Current Opinion in Rheumatology·Matthew A Brown
May 21, 2010·Current Opinion in Rheumatology·Peggy JacquesHerman Mielants
Apr 22, 2011·Current Opinion in Rheumatology·In-Ho Song, Denis Poddubnyy
Feb 2, 2013·Clinical and Translational Medicine·Markus Bosmann, Peter A Ward
Jul 14, 2009·Arthritis Research & Therapy·Lode Melis, Dirk Elewaut
Jul 30, 2009·Genome Medicine·Rhodri Ll SmithJane Worthington
Jun 23, 2009·Joint, Bone, Spine : Revue Du Rhumatisme·Anikó VégváriZoltán Szekanecz
Nov 8, 2011·Annual Review of Pathology·Gayathri K PereraFrank O Nestle
Dec 2, 2014·Rheumatic Diseases Clinics of North America·Dinny Wallis, Robert D Inman
Nov 22, 2014·Dermatologic Clinics·Satveer K MahilJonathan N Barker
Sep 24, 2009·Current Rheumatology Reports·John D Reveille

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.