Abstract
The synthesis of Hb F has been found to be unbalanced in a number of conditions, including homozygous HPFH, sickle-cell anemia, and normal term cord bloods. In this study, the counts from the pre-gamma and pre-alpha zones of the chain separation chromatogram are considered to be modified gamma and alpha chains, respectively, and are included in calculating the gamm/alpha ratios for cord blood and sickle-cell blood. The gamma chain is labeled about 52% as efficiently as the alpha chain in reticulocytes. It is possible that nu chain synthesis is balanced in the bone marrow, but subsequently becomes unbalanced in the reticulocyte.
References
Apr 7, 1976·Journal of Chromatography·W A Schroeder, L A Pace
Mar 27, 1979·Biochimica Et Biophysica Acta·E C AbrahamT H Huisman
Jan 1, 1979·American Journal of Hematology·A E FeliceT H Huisman
Dec 1, 1977·Biochemical Genetics·B RingelhannT H Huisman
Jan 1, 1977·Hemoglobin·T H Huisman
Mar 1, 1976·Cell·B G ForgetD Housman
Dec 23, 1976·The New England Journal of Medicine·B P AlterD G Nathan
Jan 1, 1975·British Journal of Haematology·K SofroniadouG Stamatoyannopoulos
Mar 1, 1976·British Journal of Haematology·S FriedmanV Ahern
Dec 1, 1974·Pediatric Research·S FriedmanE Schwartz
Jan 1, 1972·Biochimie·N BlumG Schapira
Aug 1, 1973·The Journal of Clinical Investigation·H Bard
Aug 1, 1974·The Journal of Clinical Investigation·C L NattaA Bank
Apr 14, 1972·Biochemical and Biophysical Research Communications·A V RobertsJ B Clegg
Jan 20, 1972·The New England Journal of Medicine·Y W KanD G Nathan
May 28, 1969·Journal of Molecular Biology·A S Braverman, A Bank
Aug 1, 1966·Journal of Molecular Biology·J B CleggD J Weatherball
Jun 16, 1980·Biochemical and Biophysical Research Communications·M T Makler
Jan 30, 1981·Biochimica Et Biophysica Acta·E C Abraham
Mar 1, 1980·Pediatric Research·A E FeliceT H Huisman
Oct 8, 1962·Biochimica Et Biophysica Acta·W A SCHROEDERW D FENNINGER
Nov 14, 1964·Nature·E R BURKA, P A MARKS
Jan 1, 1965·The Journal of Clinical Investigation·R F RIEDER, D J WEATHERALL