The imbalance of chain synthesis in hemoglobin F

Hemoglobin
C RogersD Powars

Abstract

The synthesis of Hb F has been found to be unbalanced in a number of conditions, including homozygous HPFH, sickle-cell anemia, and normal term cord bloods. In this study, the counts from the pre-gamma and pre-alpha zones of the chain separation chromatogram are considered to be modified gamma and alpha chains, respectively, and are included in calculating the gamm/alpha ratios for cord blood and sickle-cell blood. The gamma chain is labeled about 52% as efficiently as the alpha chain in reticulocytes. It is possible that nu chain synthesis is balanced in the bone marrow, but subsequently becomes unbalanced in the reticulocyte.

References

Apr 7, 1976·Journal of Chromatography·W A Schroeder, L A Pace
Mar 27, 1979·Biochimica Et Biophysica Acta·E C AbrahamT H Huisman
Dec 23, 1976·The New England Journal of Medicine·B P AlterD G Nathan
Jan 1, 1975·British Journal of Haematology·K SofroniadouG Stamatoyannopoulos
Mar 1, 1976·British Journal of Haematology·S FriedmanV Ahern
Dec 1, 1974·Pediatric Research·S FriedmanE Schwartz
Aug 1, 1973·The Journal of Clinical Investigation·H Bard
Aug 1, 1974·The Journal of Clinical Investigation·C L NattaA Bank
Apr 14, 1972·Biochemical and Biophysical Research Communications·A V RobertsJ B Clegg
Jan 20, 1972·The New England Journal of Medicine·Y W KanD G Nathan
May 28, 1969·Journal of Molecular Biology·A S Braverman, A Bank
Jun 16, 1980·Biochemical and Biophysical Research Communications·M T Makler
Mar 1, 1980·Pediatric Research·A E FeliceT H Huisman
Oct 8, 1962·Biochimica Et Biophysica Acta·W A SCHROEDERW D FENNINGER

❮ Previous
Next ❯

Citations

Jan 1, 1983·Hemoglobin·K IshiguroK Nakaizumi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.