The immature platelet fraction in hypertensive disease during pregnancy

Archives of Gynecology and Obstetrics
Ulrike BernsteinAlexander Jank

Abstract

The aim of our study was to elucidate the role of IPF in preeclampsia, because the immature platelet fraction (IPF) is available in most emergency departments. A number of parameters have been introduced to diagnose preeclampsia/HELLP syndrome. The defined cutoffs of angiogenic and antiangiogenic parameters, soluble fms-like tyrosine kinase 1 and placental growth factor, have been approved for clinical routine. However, these parameters need complex analysis and are expensive. The data of 69 pregnant women between 20 and 42 weeks of gestation were analyzed in this retrospective monocentric study. 28 of them had preeclampsia, HELLP syndrome or partial HELLP syndrome fitting the Tennessee criteria (study group 1). Furthermore, 41 normotensive pregnant women were included as controls (study group 2). In both groups the IPF was analyzed. In this study, we demonstrated that the values of IPF were significantly higher in patients with hypertensive diseases than in normotensives, but could not distinguish between preeclampsia and HELLP syndrome. The absolute number of immature platelets of women with preeclampsia was significantly higher and those of HELLP syndrome were significantly lower than values of healthy women. The absolute nu...Continue Reading

References

Feb 1, 1990·American Journal of Obstetrics and Gynecology·B M Sibai
Jan 1, 1994·American Journal of Obstetrics and Gynecology·H M RinderB R Smith
May 26, 2009·Seminars in Perinatology·Lelia Duley
Mar 4, 2011·Seminars in Thrombosis and Hemostasis·Rashid S KazmiBashir A Lwaleed
May 7, 2011·British Journal of Clinical Pharmacology·Laura A MageeUNKNOWN CHIPS Study Group
Sep 21, 2011·Clinical Science·Stefan VerlohrenRalf Dechend
Sep 27, 2014·Women's Health·Hind N MoussaBaha M Sibai
Nov 21, 2015·Platelets·Daniela MoraesCarlos E Poli-de-Figueiredo
Jul 10, 2017·Archives of Gynecology and Obstetrics·Ahmed M MagedMaha Katta
Nov 21, 2017·Pregnancy Hypertension·Ulrike RatschAlexander Jank

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Citations

Jan 5, 2021·Frontiers in Medicine·Hollie M Reeves, Robert W Maitta

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