PMID: 7540649Jul 1, 1995Paper

The immediate phase of c-kit ligand stimulation of mouse bone marrow-derived mast cells elicits rapid leukotriene C4 generation through posttranslational activation of cytosolic phospholipase A2 and 5-lipoxygenase

The Journal of Experimental Medicine
M MurakamiJ P Arm

Abstract

c-kit ligand (KL) activated mouse bone marrow-derived mast cells (BMMC) for the dose- and time-dependent release of arachidonic acid from cell membrane phospholipids, with generation of leukotriene (LT) C4 in preference to prostaglandin (PG)D2. KL at concentrations of 10 ng/ml elicited half-maximal eicosanoid generation and at concentrations of > 50 ng/ml elicited a maximal generation of approximately 15 ng LTC4 and 1 ng PGD2 per 10(6) cells, with 20% net beta-hexosaminidase release 10 min after stimulation. Of the other cytokines tested, none, either alone or in combination with KL, elicited or modulated the immediate phase of mediator release by BMMC, indicating strict specificity for KL. Activation of BMMC in response to KL was accompanied by transient phosphorylation of cytosolic phospholipase A2 and reversible translocation of 5-lipoxygenase to a cell membrane fraction 2-5 min after stimulation, when the rate of arachidonic acid release and LTC4 production were maximal. BMMC continuously exposed to KL in the presence of IL-10 and IL-1 beta generated LTC4 in marked preference to PGD2 over the first 10 min followed by delayed generation of PGD2 with no LTC4 over several hours. Pharmacologic studies revealed that PGD2 generat...Continue Reading

References

Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·T Hla, K Neilson
Sep 1, 1992·The Journal of Experimental Medicine·R AlamJ A Grant
Jun 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M K O'BanionD A Young
Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M TsaiS J Galli
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·W L XieD L Simmons
Jan 1, 1989·The Journal of Experimental Medicine·J Van SnickR J Simpson
Apr 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·T IshizakaJ Axelrod
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·R A CopelandJ M Trzaskos
Aug 2, 1994·Proceedings of the National Academy of Sciences of the United States of America·B K LamK F Austen
Feb 1, 1994·Immunology Today·M M HamawyR P Siraganian
Nov 3, 1993·Biochimica Et Biophysica Acta·I KudoK Inoue
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J A MitchellJ R Vane
Jan 29, 1993·Cell·L L LinR J Davis

❮ Previous
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Citations

Dec 18, 2001·European Journal of Immunology·M R WoolhiserD D Metcalfe
Aug 7, 1999·Clinical Reviews in Allergy & Immunology·R L Bell, R R Harris
Sep 13, 2006·Archives of Pharmacal Research·Ju Sun KimHyeun Wook Chang
Sep 18, 1999·Archives of Pharmacal Research·H H KimY Jahng
Apr 15, 2008·Archives of Pharmacal Research·Ming Shan ZhengHyeun Wook Chang
Dec 23, 2008·Archives of Pharmacal Research·Ju Hye YangHyeun Wook Chang
May 11, 1999·The American Journal of Pathology·E CampbellN W Lukacs
Feb 11, 2000·The Journal of Allergy and Clinical Immunology·C O Bingham, K F Austen
Dec 1, 1996·Current Opinion in Immunology·M A Beaven, R A Baumgartner
Feb 27, 1999·Current Opinion in Immunology·S J GalliC S Lantz
Mar 27, 2001·Immunology and Cell Biology·P H Hart
Dec 22, 1998·The Journal of Experimental Medicine·M MaurerS J Galli
Dec 23, 1999·Current Opinion in Hematology·S J Galli
Nov 1, 1995·Allergy·S J Galli, J J Costa
Aug 30, 2012·The American Journal of Chinese Medicine·Hyuk-Hwan SongYoung-Won Chin
Jan 1, 1996·Mediators of Inflammation·Y S Bakhle, R M Botting
Jan 12, 2005·Arthritis Research & Therapy·Peter A Nigrovic, David M Lee
Jun 10, 2004·Biological & Pharmaceutical Bulletin·Seung Ho LeeHyeun Wook Chang
Jan 7, 2005·Biological & Pharmaceutical Bulletin·Tae Chul MoonHyeun Wook Chang
Feb 8, 2006·Biological & Pharmaceutical Bulletin·Eunkyung LeeHyeun Wook Chang
May 3, 2006·Biological & Pharmaceutical Bulletin·Mei Hua JinHyeun Wook Chang
Aug 19, 2010·International Journal of Molecular Sciences·You-Chang OhDong-Yeul Kwon
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·H FujishimaJ P Arm
Aug 31, 2010·Biochemical and Biophysical Research Communications·Ke TangBo Huang
Sep 21, 2015·International Immunopharmacology·Hee-Sung ChaeYoung-Won Chin
Sep 2, 2006·Biochimica Et Biophysica Acta·Barbara Balestrieri, Jonathan P Arm
Jan 13, 2015·Allergology International : Official Journal of the Japanese Society of Allergology·Makoto Murakami, Yoshitaka Taketomi
Jan 11, 2012·Immunopharmacology and Immunotoxicology·Hee-Sung ChaeYoung-Won Chin
Aug 23, 2011·Immunopharmacology and Immunotoxicology·Hee-Sung Chae, Young-Won Chin
Mar 16, 2011·Immunopharmacology and Immunotoxicology·Hee-Sung ChaeDong-Yeul Kwon
Sep 18, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yue LuHyeun Wook Chang
Dec 14, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yue LuHyeun Wook Chang

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