The immune checkpoint CD96 defines a distinct lymphocyte phenotype and is highly expressed on tumor-infiltrating T cells

Immunology and Cell Biology
Ailin LepletierJohn J Miles

Abstract

CD96 has recently been shown to be a potent immune checkpoint molecule in mice, but a similar role in humans is not known. In this study, we provide a detailed map of CD96 expression across human lymphocyte lineages, the kinetics of CD96 regulation on T-cell activation and co-expression with other conventional and emerging immune checkpoint molecules. We show that CD96 is predominantly expressed by T cells and has a unique lymphocyte expression profile. CD96high T cells exhibited distinct effector functions on activation. Of note, CD96 expression was highly correlated with T-cell markers in primary and metastatic human tumors and was elevated on antigen-experienced T cells and tumor-infiltrating lymphocytes. Collectively, these data demonstrate that CD96 may be a promising immune checkpoint to enhance T-cell function against human cancer and infectious disease.

References

Nov 26, 2008·The Journal of Experimental Medicine·Akiko Iguchi-ManakaAkira Shibuya
Nov 26, 2008·The Journal of Experimental Medicine·Susan GilfillanMarco Colonna
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Jun 26, 2010·Current Protocols in Cytometry·Nikesh KotechaJonathan M Irish
Aug 30, 2012·Oncotarget·Valentina BevelacquaGrazia Malaponte
Jan 23, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Henrik E MeiHolden T Maecker
Apr 11, 2015·Cancer Cell·Suzanne L TopalianDrew M Pardoll
Apr 14, 2015·The Journal of Clinical Investigation·Joe-Marc ChauvinHassane M Zarour
Apr 22, 2015·The New England Journal of Medicine·Michael A PostowF Stephen Hodi
Jun 2, 2015·The New England Journal of Medicine·James LarkinJedd D Wolchok
Sep 29, 2015·The Journal of Clinical Investigation·Sema KurtulusAna C Anderson
Jan 24, 2016·Cellular and Molecular Life Sciences : CMLS·Camille GuillereyMark J Smyth
Jun 4, 2016·Journal of Leukocyte Biology·Anna E VilgelmAnn Richmond
Nov 3, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stephen J BlakeMark J Smyth
Mar 5, 2017·Immunological Reviews·Elizabeth C NowakRandolph J Noelle
Mar 5, 2017·Immunological Reviews·William C DougallAna C Anderson
Mar 5, 2017·Immunological Reviews·Madhumita DasVijay K Kuchroo
Mar 5, 2017·Immunological Reviews·Joseph R Podojil, Stephen D Miller
Jan 1, 2018·Cancer Immunology, Immunotherapy : CII·Helen M McGuirePeter Hersey
May 15, 2018·The Journal of Clinical Investigation·Xian-Yang LiMark J Smyth

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Citations

Jan 11, 2020·Immunology and Cell Biology·Anne C La Flamme
Mar 22, 2019·Cancer Immunology Research·Deepak MittalMark J Smyth
Mar 11, 2021·Cancer Discovery·Zoya AlteberEran Ophir

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