The immune response against anti-idiotope antibodies. I. Induction of idiotope-bearing antibodies and analysis of the idiotope repertoire

European Journal of Immunology
T TakemoriK Rajewsky

Abstract

In the present analysis we dissect the idiotype repertoire, independently of hapten-binding specificity, by immunizing different strains of mice with cross-linked monoclonal anti-idiotope antibodies against antibody B1-8. B1-8 is a monoclonal antibody with specificity for the hapten (4-hydroxy-3-nitro-phenyl)acetyl (NP) and carries a germ line gene-encoded variable region. The results demonstrate that the expression of B1-8 idiotopes and their association with each other and with NP-binding specificity are strain-specific. Certain idiotopes are expressed on antibodies differing in antigen-binding specificity, whereas one of the idiotopes appears strictly associated with NP-binding antibodies. The genetic analysis provides strong evidence that the strain specificity of the idiotope repertoire is a result of V region polymorphism in the mouse.

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Citations

Jan 1, 1986·Immunogenetics·S NishikawaY Katsura
May 1, 1994·Veterinary Immunology and Immunopathology·H Zhang, A J Ainsworth
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Jul 1, 1985·European Journal of Immunology·P LymberiS Avrameas
Jul 1, 1984·European Journal of Immunology·B J BastJ F Kearney

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