The immune response and immunopathology in infection with Schistosoma mansoni: a key role of major egg antigen Sm-p40

Parasite Immunology
M J Stadecker, H J Hernandez

Abstract

The immune response and related granulomatous inflammation in infection with Schistosoma mansoni are ultimately dependent on SEA-sensitized CD4+ Th cells and comprise multiple pathways variously involving the activation and recruitment of different cell populations and the production of different inflammatory cytokines, all under the influence of regulatory genetic factors. The spontaneous downregulation of granuloma formation (immunomodulation), in turn, is a well-known phenomenon, but the full extent of its precipitating factors is still uncertain. This review describes a pathway leading to immunomodulation that features at its centre the down-regulatory cytokine IL-10. This mechanism is attractive because it offers a cogent correlation between findings in the laboratory and those displayed by patients affected with the disease. The Sm-p40 antigen, a major component of schistosome eggs, elicits a strong CD4+ Th cell response in H-2k mice that correlates with intense granuloma formation; in contrast, its immunogenicity is relatively minor during infection of other mouse strains that develop smaller granulomas. Of great interest is that the Sm-p40 antigen only elicits a Th-1 type cytokine response, a phenotype that remains cons...Continue Reading

References

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Citations

Jun 23, 2005·International Journal for Parasitology·David L WilliamsMiguel J Stadecker
Dec 11, 2003·Parasitology International·Hiroko Asahi, Miguel J Stadecker
Mar 27, 1999·Journal of Women's Health
Oct 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·L I RutitzkyM J Stadecker
Feb 14, 2016·Veterinary Parasitology·Christian HidalgoRodolfo Paredes
Sep 14, 2004·Immunological Reviews·Miguel J StadeckerJing Sun
Dec 18, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Soad HanallahSanaa Botros
Jan 18, 2011·International Journal for Parasitology·Saskia DewalickJaap J van Hellemond
Jul 6, 2016·Frontiers in Pharmacology·Mauricio G ZaiaFernanda de Freitas Anibal
Jun 30, 2012·Journal of the International Association of Providers of AIDS Care·Kennedy D MwambeteMary Justin-Temu
Dec 10, 2002·Memórias do Instituto Oswaldo Cruz·Allen W CheeverZilton A Andrade
Nov 22, 2017·Parasites & Vectors·Anna SulimaDaniel Młocicki
Mar 7, 2007·Journal of the Royal Society of Medicine·Heather Milburn
Aug 7, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laura I RutitzkyMiguel J Stadecker
Dec 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laura I RutitzkyMiguel J Stadecker
Nov 22, 2017·Revista Da Sociedade Brasileira De Medicina Tropical·Renata Russo Frasca CandidoCarlos Graeff-Teixeira
Mar 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Razvan ArsenescuJoel V Weinstock
Nov 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laura H HoganMatyas Sandor

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