The immune response and maternal antibody interference to a heterologous H1N1 swine influenza virus infection following vaccination

Veterinary Immunology and Immunopathology
Pravina KitikoonEileen L Thacker

Abstract

This study investigated the efficacy of a bivalent swine influenza virus (SIV) vaccine in piglets challenged with a heterologous H1N1 SIV isolate. The ability of maternally derived antibodies (MDA) to provide protection against a heterologous challenge and the impact MDA have on vaccine efficacy were also evaluated. Forty-eight MDA(+) pigs and 48 MDA(-) pigs were assigned to 8 different groups. Vaccinated pigs received two doses of a bivalent SIV vaccine at 3 and 5 weeks of age. The infected pigs were challenged at 7 weeks of age with an H1N1 SIV strain heterologous to the H1N1 vaccine strain. Clinical signs, rectal temperature, macroscopic and microscopic lesions, virus excretion, serum and local antibody responses, and influenza-specific T-cell responses were measured. The bivalent SIV vaccine induced a high serum hemagglutination-inhibition (HI) antibody titer against the vaccine virus, but antibodies cross-reacted at a lower level to the challenge virus. This study determined that low serum HI antibodies to a challenge virus induced by vaccination with a heterologous virus provided protection demonstrated by clinical protection and reduced pneumonia and viral excretion. The vaccine was able to prime the local SIV-specific a...Continue Reading

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Citations

Dec 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Wenjun MaJürgen A Richt
Mar 26, 2009·Virology Journal·Donruethai SretaRoongroje Thanawongnuwech
Sep 30, 2010·Emerging Infectious Diseases·Donruethai SretaPravina Kitikoon
Mar 28, 2008·The Journal of Infectious Diseases·Eileen Thacker, Bruce Janke
Mar 29, 2012·Veterinary Research·Meritxell Simon-GriféJordi Casal
Oct 18, 2012·Influenza Research and Treatment·Janice R Ciacci ZanellaMarie R Gramer
May 14, 2010·Animal Health Research Reviews·Wenjun Ma, Jürgen A Richt
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Mar 26, 2013·Molecular Immunology·Elisa CrisciMaria Montoya
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Jun 15, 2011·Veterinary Immunology and Immunopathology·Ratree PlattJames A Roth
Apr 20, 2011·Veterinary Immunology and Immunopathology·Iwona Markowska-DanielZygmunt Pejsak
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Jan 21, 2015·Veterinary Microbiology·Jamie N HenningsonAmy L Vincent
Jul 6, 2012·Veterinary Microbiology·Aunyaratana ThontiravongAlongkorn Amonsin

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