PMID: 6979569Jul 1, 1982Paper

The immune response in aged C57BL/6 mice. II. Characterization and reversal of a defect in the ability of aged spleen cells to respond to the adjuvant properties of Fc fragments

The Journal of Immunology : Official Journal of the American Association of Immunologists
E L Morgan, W O Weigle

Abstract

Fc fragments derived from papain cleavage of human Ig were found to be unable to enhance the in vitro anti-SRBC response of aged mice. The inability of aged spleen cells to respond to the adjuvant properties of Fc fragments is localized to the aged T cell population. The addition of Fc fragments to cultures of aged B cells and young adult T cells, but not young adult B cells and aged T cells, resulted in an enhanced anti-SRBC response. The Fc fragment adjuvant defect in spleen cells from aged mice can be reversed by the addition of IL 2 to culture. The addition of either Fc fragments alone or IL 2 alone with antigen to intact aged spleen cell populations did not result in an enhanced anti-SRBC response. When aged spleen cell cultures receive both Fc and IL 2, however, a marked enhancement is observed. These data indicate that IL 2 action on aged spleen cells results in the acquisition of reactivity to Fc adjuvant action by aged mice.

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