The immune response of offspring mice from mothers immunized during pregnancy with protein antigens.

Journal of Reproductive Immunology
A Malley

Abstract

The immune system of offspring mice from mothers immunized with photo-oxidized timothy grass pollen antigen B (OX-AgB) or Trinitrophenyl-bovine gamma globulin (TNP-BGG) during their pregnancy was examined. Offspring mice immunized 6 or 8 weeks after delivery with the same antigen administered to their mothers have completely suppressed primary responses and greater than 80% suppressed secondary responses. The observed immunosuppression in offspring mice appears to persist until about 16 weeks after delivery, and is antigen-specific. Adoptive transfer studies show that spleen cells from adult OX-AgB primed mice injected i.v. into lethally X-irradiated (800 rads) syngeneic recipients and challenged with antigen produce significant levels of AgB-specific IgG antibody. Spleen cells (5 x 10(6] from offspring mice of mothers immunized with OX-AgB during their pregnancy were added to spleen cells from adult OX-AgB primed mice and injected i.v. into lethally X-irradiated syngeneic recipients and challenged with antigen. These recipients showed a significantly (greater than 85%) immunosuppressed secondary response. The observed immunosuppression appears to be mediated by CD4+ and CD8+ T cells suggesting a requirement for both T suppress...Continue Reading

References

Mar 1, 1976·British Journal of Obstetrics and Gynaecology·O M PetruccoR G Symons
Jan 1, 1976·Journal of Reproduction and Fertility·J Carter
Jan 1, 1985·International Archives of Allergy and Applied Immunology·A MalleyK J Turner
Nov 3, 1988·The New England Journal of Medicine·R A Insel
Dec 1, 1968·The Journal of Pediatrics·D J Lang, B Noren
Jun 29, 1972·The New England Journal of Medicine·J M AaseJ W Geme
Sep 1, 1983·The Journal of Clinical Investigation·T J GillA L Cortese

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Citations

Sep 1, 1992·Baillière's Clinical Obstetrics and Gynaecology·W D Billington
Apr 1, 1992·Biulleten' eksperimental'noĭ biologii i meditsiny·M Iu RubtsovaA B Poletaev

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