PMID: 6025321Jun 1, 1967Paper

The immune response to foreign red blood cells and the participation of short-lived lymphocytes

The Journal of Experimental Medicine
C G CraddockJ S Lawrence

Abstract

The sequence of morphological changes in the rat spleen following SRBC injection associated with hemolysin production has been correlated with estimates of proliferative activity by splenic lymphatic tissue. Formation of new, reactive germinal centers containing macrophages which engulf nuclear debris is a prominent feature of the response. This is prevented by pretreatment of the animal with cortisol. Indirect evidence is provided that short-lived lymphocytes produced in germinal centers may be a necessary component in the induction of other cells to proliferate and differentiate into hemolysin-producing cells. The reasons are discussed for considering short-lived lymphocytes, such as those produced in the thymus, bone marrow, and germinal centers, as differing from long-lived lymphocytes capable of antibody synthesis.

References

Jan 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·H N Claman
Mar 1, 1966·The Journal of Experimental Medicine·M MatsuyamaD Metcalf
Jul 1, 1966·Transplantation·A J DaviesP C Koller
Nov 1, 1957·The Journal of Infectious Diseases·G J THORBECKEJ A REYNIERS
Sep 5, 1958·Annals of the New York Academy of Sciences·J W REBUCKJ M RIDDLE
May 11, 1963·Nature·M FISHMANV P BOND
Mar 1, 1963·The Journal of Cell Biology·S ITO, R J WINCHESTER
May 1, 1963·The Journal of Experimental Medicine·F J DIXON, P J McCONAHEY
Aug 7, 1964·Science·H H FUDENBERG, K HIRSCHHORN
Jun 19, 1964·Science·A M SILVERSTEIN
Sep 1, 1964·The Journal of Experimental Medicine·C G CRADDOCKL M VANSLAGER
Feb 12, 1965·Science·A NORMANA G FINGERHUT
Jan 1, 1965·Acta Haematologica·C G CRADDOCK

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Citations

Aug 12, 1971·The New England Journal of Medicine·C G CraddockR McMillan
Oct 1, 1968·The Journal of Experimental Medicine·E R Hurd, M Ziff
Mar 1, 1970·The Journal of Experimental Medicine·J Thompson, R van Furth
Sep 1, 1991·The American Review of Respiratory Disease·B E NoyesJ H Dauber
Sep 1, 1973·The Journal of Clinical Investigation·A Winkelstein
Nov 1, 1972·The American Journal of Medicine·J D Baxter, P H Forsham
Dec 1, 1975·Experimental and Molecular Pathology·L D Loose, N R Di Luzio
Nov 2, 1968·Lancet·I CatH Braga
Nov 2, 1968·Lancet·G MelliC Bazzi

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