PMID: 6027644Jul 1, 1967Paper

The immune response to sheep erythrocytes in the mouse. I. A study of the immunological events utilizing the plaque technique

The Journal of Experimental Medicine
D Eidinger, H F Pross

Abstract

The direct and indirect plaque technique for the detection of antibody-forming cells against sheep erythrocytes was utilized for the investigation of a number of biological parameters of the primary and secondary immune response on a cellular level. The sequential pattern of 19S followed by 7S antibody formation was elicited in the primary response after a latent period of at least 1-2 days and 2-3 days respectively. The secondary response initiated 140 days after primary immunization, in contrast, was characterized by the simultaneous appearance of 19S and 7S antibody-forming cells after an observed latent period of 2-3 days. The cellular dynamics of the recruitment phase of the respective immunoglobulins in the primary and secondary response was interpreted as evidence for the derivation of the two classes of immunoglobulins from separate progenitors. The 19S antibody-forming cells were derived predominantly by a process of transformation and maturation and 7S antibody formers by a process of cellular division with a doubling time of about 12 hr. The draining lymph node exhibited maximal immunological reactivity due to its capacity to retain the particulate antigen. This capacity was considerably enhanced in the sensitized dr...Continue Reading

References

Sep 1, 1965·The Journal of Experimental Medicine·M LandyA L Jackson
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Mar 29, 1957·Science·H F DEUTSCH, J I MORTON
Aug 1, 1961·British Journal of Experimental Pathology·A H MARSHALL, R G WHITE
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Aug 1, 1965·The Journal of Experimental Medicine·Y BORELP A MIESCHER
Jun 1, 1965·The Journal of Experimental Medicine·G MOLLER, H WIGZELL

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Citations

Nov 1, 1972·The Journal of Experimental Medicine·D Eidinger, T J Garrett
Jan 1, 1969·Transplantation Reviews·J F Miller, G F Mitchell
Jan 1, 1980·Cellular Immunology·D A Lawrence
Mar 19, 1971·Nature·C M O'Toole, A J Davies
Feb 1, 1969·Japanese Journal of Medical Science & Biology·S Asakawa

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