Mar 3, 2020

The immune system fails to mount a protective response to Gram-positive or Gram-negative bacterial prostatitis

bioRxiv
Federico LupoMolly A Ingersoll

Abstract

Bacterial prostatitis affects 1% of men, with increased incidence in the elderly. It is defined by the frequency and urgency to urinate, localized pain, and positive bacterial cultures in expressed seminal fluids. Acute bacterial prostatitis frequently progresses to chronicity, which is marked by recurrent acute episodes interspersed with asymptomatic periods of variable duration. Up to 80% of bacterial prostatitis cases are caused by Gram-negative uropathogenic E. coli (UPEC) or Gram-positive E. faecalis. Antibiotic treatment is standard of care, however, global dissemination of antimicrobial resistant uropathogens threatens efficacy of therapy. Thus, development of non-antibiotic-based approaches to treat bacterial prostatitis is a priority. One challenge is that the immune response to infection in the prostate is incompletely understood. We used a mouse model of transurethral bacterial instillation to study the immune response to UPEC or E. faecalis prostate infection. Both uropathogens exhibited tropism for the prostate over the bladder early post-infection. UPEC infection induced greater proinflammatory cytokine expression and neutrophil and monocyte infiltration compared to E. faecalis infection. Following challenge infec...Continue Reading

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Mentioned in this Paper

Seminal Fluid
Immunotherapy
Humoral Immune Response
Instillation (Procedure)
Uropathogenic Escherichia coli
Antibiotics
Gram-Negative Bacteria
Malignant Neoplasm of Prostate
Infiltration
Escherichia Coli Infections

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