The immune thrombocytopenia syndrome: a disorder of diverse pathogenesis and clinical presentation

Hematology/oncology Clinics of North America
Douglas B Cines, Howard Liebman

Abstract

This article presents a brief history of immune thrombocytopenia (ITP) from the first clinical description written in 1735, through years of controversy about the nature and causes of what was first known as idiopathic thrombocytopenia purpura, then immune thrombocytopenic purpura, and, finally, ITP. Current understanding of ITP's primary and secondary forms and the effect of diverse defects in immune self tolerance that result in the development of antiplatelet antibodies is described. This overview is followed by a narrative list of other articles in this issue on topics ranging from a comprehensive review of the role of antiplatelet antibodies in platelet destruction and production to a review of classic treatment modalities and newer approaches to initial treatment.

References

Apr 13, 1989·The New England Journal of Medicine·T GernsheimerS J Slichter
Dec 12, 2003·Journal of Pediatric Hematology/oncology·John W Semple
Oct 16, 2007·Current Opinion in Hematology·Howard A Liebman, Roberto Stasi
Apr 28, 2009·Blood·Douglas B CinesEline T Luning Prak

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Citations

Jan 31, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hong-Wei ZhangYong-Lun Hang
Dec 19, 2012·Journal of Autoimmunity·Michael L FreemanMarcia A Blackman
Sep 27, 2013·Thrombosis and Haemostasis·Tamam BakchoulUlrich J Sachs
Sep 17, 2013·Pediatric Blood & Cancer·Michael D DeelSalvatore J Bertolone
Nov 15, 2012·Blood·Terry GernsheimerRoberto Stasi
Dec 22, 2020·Hämostaseologie·Karina AlthausTamam Bakchoul
Mar 7, 2021·Journal of Clinical Medicine·Anurag SinghTamam Bakchoul

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