The immune tissues of the endangered red-tailed phascogale (Phascogale calura)

Journal of Anatomy
J M OldElizabeth M Deane

Abstract

The lymphoid tissues of the red-tailed phascogale (Phascogale calura) were examined using histological and immunohistochemical techniques. The distribution of immune cells in the tissue beds was documented using antibodies to surface markers CD3 and an MHC Class II antigen (equivalent to HLA DRII). Spleen, gut-associated lymphoid tissues (GALT), lung, bronchus-associated lymphoid tissue (BALT) and liver were examined. The spleen had defined areas of red and white pulp, with follicles containing tingible-bodied macrophages. Anti-CD3 and anti-HLA DRII antibodies revealed the presence of T cells in areas of white pulp and around the peri-arterial lymphatic sheaths. GALT and BALT were detected and appeared as scattered areas of lymphocytes in the tissues beds. This is the first study to report on the lymphoid tissues of this endangered species of marsupial and the first report of the capacity of anti-human antibodies to a surface MHC molecule to react with Dasyurid cells.

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Oct 5, 2002·Journal of Anatomy·Julie M Old, Elizabeth M Deane
Oct 16, 2002·Developmental and Comparative Immunology·J M Old, E M Deane
Feb 18, 2003·Journal of Anatomy·Richard W Young

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Citations

Jan 11, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Emily S W WongKatherine Belov
Nov 26, 2015·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Casey R Borthwick, Julie M Old
Apr 22, 2009·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Alexandre KreissGregory M Woods
May 24, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Casey R BorthwickJulie M Old
Jan 1, 2021·Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology·Julie M OldHayley J Stannard

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