The Immunobiology of Receptor Activator for Nuclear Factor Kappa B Ligand and Myeloid-Derived Suppressor Cell Activation in Immunoglobulin G4-Related Sclerosing Cholangitis

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Min LianXiong Ma

Abstract

The primary function of myeloid-derived suppressor cells (MDSCs) is reflected in their immune modulatory role in several immune-mediated diseases. In immunoglobulin G4 (IgG4)-related disease (IgG4-RD), it has been hypothesized that there are selective regulatory defects that lead to a T helper 2 (Th2) bias immune response. Herein we have taken advantage of a large cohort of patients with IgG4-related sclerosing cholangitis (IgG4-SC), the most common extrapancreatic involvement of IgG4-RD, as well as controls consisting of primary sclerosing cholangitis, autoimmune hepatitis, and healthy volunteers, to study MDSCs. We report dramatically increased levels of receptor activator for nuclear factor kappa B ligand (RANKL) expression in serum and liver from patients with IgG4-SC compared to both liver-disease and healthy controls. Moreover, in IgG4-SC liver, RANKL-secreting cells specifically colocalized with cluster of differentiation 38-positive plasma cells and MDSCs, particularly monocytic MDSCs, and express the RANKL receptor in liver. Similarly, the frequency and number of peripheral blood MDSCs were significantly increased. Importantly, serum expression levels of RANKL were inversely correlated with the serum level of gamma-glu...Continue Reading

References

Sep 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eilidh WilliamsonJoanne L Viney
Apr 28, 2006·Journal of Cellular Physiology·Tanjanika DanielMartin G Schwacha
Jun 10, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elke M HennesUNKNOWN International Autoimmune Hepatitis Group
Oct 10, 2008·The Journal of Investigative Dermatology·Ryutaro YoshikiYoshiki Tokura
Jan 27, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Roger ChapmanUNKNOWN American Association for the Study of Liver Diseases
Jul 29, 2010·Seminars in Liver Disease·Thomas A Wynn, Luke Barron
Nov 12, 2010·Trends in Immunology·Thomas Condamine, Dmitry I Gabrilovich
Jun 26, 2012·Journal of Autoimmunity·Zhengrui YouXiong Ma
Jul 10, 2012·Nature Medicine·Thomas A Wynn, Thirumalai R Ramalingam
Aug 17, 2012·Gut·Shahid A KhanUNKNOWN British Society of Gastroenterology
Oct 5, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Huanfa YiXiang-Yang Wang
Jan 10, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lucas J Maillette de Buy WennigerUlrich Beuers
Mar 5, 2013·The Journal of Clinical Investigation·David Vasquez-DunddelYoung Kim
Oct 12, 2013·Annual Review of Pathology·Vinay S MahajanJohn H Stone
Feb 26, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Guangwei LiuRuifu Yang
Jun 4, 2014·Arthritis & Rheumatology·Isabelle JéruSerge Amselem
Jul 30, 2014·Gastroenterology·Fabio Marra, Frank Tacke
Oct 21, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Linda HammerichFrank Tacke
Apr 14, 2015·Clinical and Experimental Immunology·E Della-TorreC Doglioni
May 12, 2015·Nature Medicine·Laura J PallettMala K Maini
Jan 30, 2016·Expert Review of Clinical Immunology·Jinjung ChoiM Eric Gershwin
Mar 12, 2016·Gut·Masahiro ShiokawaTsutomu Chiba
May 10, 2016·Nature Reviews. Disease Primers·Jorg KleeffJohn P Neoptolemos
May 27, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David Kung-Chun ChiuCarmen Chak-Lui Wong
Jul 1, 2016·Annals of the Rheumatic Diseases·Takashi MaeharaShiv S Pillai
Jul 7, 2016·Nature Communications·Vincenzo BronteDmitry I Gabrilovich
Jul 22, 2016·Nature Reviews. Rheumatology·Caroline Barranco
Sep 16, 2016·PloS One·Ana LleoPietro Invernizzi
Aug 5, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Haiyan ZhangXiong Ma

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Citations

Jul 12, 2018·International Journal of Cancer. Journal International Du Cancer·Zhongnan YinLixiang Xue
May 22, 2019·Journal of Digestive Diseases·Atsushi Tanaka
Feb 9, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zhengrui YouXiong Ma

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