The immunobiology of the mammalian epididymis: the black box is now open!

Basic and Clinical Andrology
Rachel GuitonJoël R Drevet

Abstract

Spermatozoa represent an immunologic challenge for the mammalian males. They are produced long after the establishment of the immune library of the individual and harbor specific spermatic antigens that are found nowhere else in other organs, tissues and cells. Consequently, spermatozoa are somehow "foreign" to the male adaptive immune system. In order not to elicit autoimmune responses that would be detrimental for male fertility, spermatozoa should be either physically separated from the adaptive immune response and/or, the immune system challenged by spermatic antigens must be efficiently silenced. Within the mammalian male genital tract it becomes more and more obvious that a range of strategies are at stake to ensure that the immune-stranger spermatozoa do not constitute an immunological issue. In this review the focus will be on the immune status of the epididymis tubule, in which spermatozoa that have left the testes will mature for approximately 2 weeks and may be stored for prolonged period of time. How the epididymal immune environment compares to that of the testis and what are the immune regulatory processes at work in the epididymal compartment will only be briefly described. Instead, this review will focus on rece...Continue Reading

References

Feb 1, 1989·International Journal of Andrology·D NashanE Nieschlag
Aug 1, 1980·Archives of Biochemistry and Biophysics·R YoshidaO Hayaishi
Feb 1, 1993·Biology of Reproduction·R S PappasD E Ong
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·S H Kaufmann
Oct 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·C J SmithP C Isakson
May 12, 2000·Immunological Reviews·D G Doherty, C O'Farrelly
Nov 4, 2000·Biochimica Et Biophysica Acta·D E OngM C Orgebin-Crist
Feb 20, 2003·The Journal of Allergy and Clinical Immunology·Larry C Borish, John W Steinke
Oct 2, 2004·Nature Reviews. Immunology·Andrew L Mellor, David H Munn
Jun 9, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Erik KwidzinskiIngo Bechmann
Nov 8, 2005·Science·Michael PlattenLawrence Steinman
May 27, 2008·Nature Reviews. Immunology·Janine L Coombes, Fiona Powrie
Aug 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Megan S Ford McIntyreLi Zhang
Sep 17, 2008·Journal of Clinical Immunology·Yisong Y Wan, Richard A Flavell
Oct 1, 2008·Immunology Letters·Hui XuAbdolmohamad Rostami
Oct 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Victoria A BlahoCharles R Brown
Dec 18, 2009·Nature Immunology·Kajsa Wing, Shimon Sakaguchi
Jan 1, 2009·Journal of Basic and Clinical Physiology and Pharmacology·Thotakura BalajiVenugopal Padmanabhan Menon
Apr 2, 2010·Journal of Physiology and Biochemistry·S Caspar-BauguilC Carpéné
Apr 7, 2010·Molecular and Cellular Endocrinology·Andreas Meinhardt, Mark P Hedger
Apr 7, 2010·International Reviews of Immunology·Lei HuangAndrew L Mellor
Apr 21, 2010·Mucosal Immunology·L XuW Strober
Sep 17, 2010·Stem Cells·Sandrine PoglioBéatrice Cousin
Dec 30, 2010·The Journal of Biological Chemistry·Aicha Jrad-LamineJoël R Drevet
Feb 12, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·Nicolas Da SilvaSylvie Breton
Apr 15, 2011·Immunological Reviews·Santhakumar Manicassamy, Bali Pulendran
Apr 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Karen WheelerKenneth S K Tung
Jun 7, 2011·Biochemical Pharmacology·Fulvio D'Acquisto, Tessa Crompton
Jul 23, 2011·Immunity·Jason A HallYasmine Belkaid

❮ Previous
Next ❯

Citations

Jul 20, 2019·Andrology·R Wijayarathna, M P Hedger
Feb 8, 2020·Physiological Reviews·Anna Le TortorecNathalie Dejucq-Rainsford
Aug 21, 2020·Andrologia·Salah ElbashirAshok Agarwal
Mar 21, 2020·Frontiers in Immunology·Imane NafiaAntoine Italiano
Jun 17, 2016·Human Reproduction Update·Robert Sullivan, Roger Mieusset
Apr 6, 2017·Molecular Human Reproduction·Christine LégaréRobert Sullivan
Jun 30, 2016·American Journal of Reproductive Immunology : AJRI·Peng Wang, Yong-Gang Duan
May 10, 2020·Cell and Tissue Research·Rukmali WijayarathnaMark P Hedger
May 15, 2015·Asian Journal of Andrology·Nicolas Da Silva, Tegan B Smith
Aug 29, 2021·Animal Reproduction Science·Heriberto Rodriguez-MartinezCristina A Martinez-Serrano

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
dissection

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Archivos de medicina experimental; trabajos del Instituto Nacional de Ciencias Médicas
A PURAS MUNOZ, J BOTELLA LLUSIA
Biology of Reproduction
J M Cummins, M C Orgebin-Crist
Fertility and Sterility
Nieves María GabrielliMónica Hebe Vazquez-Levin
Minerva urologica e nefrologica = The Italian journal of urology and nephrology
M GallucciG D'Eramo
© 2021 Meta ULC. All rights reserved