The immunogenic peptide for Th1 development

International Immunopharmacology
Kiyoshi Takatsu, Ai Kariyone

Abstract

Th1 cells play a critical role in the induction of cell-mediated immune responses and eradication of intracellular pathogen. The dose and route of immunization of antigen are also determining factors. It remains unclear what types of immunogenic peptide can induce the Th1 development and how it acts to regulate the immune system. Ag85B (also known as alpha antigen or MPT59) has been shown to be the most potent antigen species yet purified in humans and in mice. Strong Th1 responses have been elicited in vitro from PPD(+) asymptomatic individuals and Ag85B-primed cells of C57BL/6 (I-A(b)) mice. Peptide-25 (aa240-254) of Ag85B is a major Th1 cell epitope in I-A(b) mice. Active immunization of C57BL/6 mice with Peptide-25 can induce the development of CDT4(+) TCRVbeta11(+) and CDT4(+) TCRVbeta11(-)Th1 cells that produce IFN-gamma- and TNF-alpha, and protects against subsequent infection with live Mycobacterium tuberculosis H37Rv IFN-gamma. Peptide-25 has a potent adjuvant activity in both humoral and cell-mediated immune responses that is mediated by Th1 cells. We would propose to designate Peptide-25 as "Th1-inducing peptide".

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Citations

Jun 18, 2009·Respiratory Research·Jian WuNanshan Zhong
Nov 30, 2005·Biochemical and Biophysical Research Communications·Masashi SuzukiNagahiro Minato
Jun 18, 2009·Current Opinion in Allergy and Clinical Immunology·Kaw Yan ChuaChiung-Hui Huang
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Mar 4, 2014·Nihon Hansenbyō Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association·Toshiki TamuraMasahiko Makino
Oct 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ce TangYasunobu Yoshikai
Aug 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yoshiro HanyuMieko Kato
Jul 30, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Szun S TayDavid G Bowen

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