The immunoglobulin family member dendrite arborization and synapse maturation 1 (Dasm1) controls excitatory synapse maturation

Proceedings of the National Academy of Sciences of the United States of America
Song-Hai ShiYuh Nung Jan

Abstract

In the developing mammalian brain, a large fraction of excitatory synapses initially contain only N-methyl-D-aspartate receptor and thus are "silent" at the resting membrane potential. As development progresses, synapses acquire alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPA-Rs). Although this maturation of excitatory synapses has been well characterized, the molecular basis for this developmental change is not known. Here, we report that dendrite arborization and synapse maturation 1 (Dasm1), an Ig superfamily member, controls excitatory synapse maturation. Dasm1 is localized at the excitatory synapses. Suppression of Dasm1 expression by using RNA interference or expression of dominant negative deletion mutants of Dasm1 in hippocampal neurons at late developmental stage specifically impairs AMPA-R-mediated, but not N-methyl-D-aspartate receptor-mediated, synaptic transmission. The ability of Dasm1 to regulate synaptic AMPA-Rs requires its intracellular C-terminal PDZ domain-binding motif, which interacts with two synaptic PDZ domain-containing proteins involved in spine/synapse maturation, Shank and S-SCAM. Moreover, expression of dominant negative deletion mutants of Dasm1 leads to more immature sile...Continue Reading

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Sep 2, 2004·Proceedings of the National Academy of Sciences of the United States of America·Song-Hai ShiYuh-Nung Jan

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Citations

Mar 10, 2005·Science's STKE : Signal Transduction Knowledge Environment·Douglas L Falls
Feb 13, 2008·Molecular and Cellular Biology·Archana MishraRüdiger Klein
Apr 19, 2011·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Chan-Ying ZhengRonald S Petralia
Oct 13, 2010·Molecular Brain·Scott Cameron, Yong Rao
Oct 31, 2012·Molecular Brain·Yating ZhouYong Rao
Jul 5, 2005·Proceedings of the National Academy of Sciences of the United States of America·Sanna LehtonenMarilyn G Farquhar
Jan 5, 2005·Proceedings of the National Academy of Sciences of the United States of America·Nir KalismanHenry Markram
Sep 2, 2004·Proceedings of the National Academy of Sciences of the United States of America·Song-Hai ShiYuh-Nung Jan
Feb 19, 2013·Neurochemical Research·Maria Hansen, Peter Schledermann Walmod
Jan 22, 2008·Progress in Neurobiology·Kihoon Han, Eunjoon Kim
Jan 24, 2006·Current Opinion in Neurobiology·Michael R Akins, Thomas Biederer
Sep 6, 2005·Current Biology : CB·Wesley B GrueberYuh-Nung Jan
Feb 1, 2015·Journal of Biochemistry·Shunta NagashimaYutaka Hata
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Jun 6, 2006·Journal of Biochemistry·Akira KawataYutaka Hata
May 3, 2021·The Journal of Biological Chemistry·Xiao-Xiao WangShe Chen

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